DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNNM4 and LOC100150651

DIOPT Version :9

Sequence 1:	XP_005263971.1	Gene:	CNNM4 / 26504	HGNCID:	105	Length:	796	Species:	Homo sapiens
Sequence 2:	XP_021332085.1	Gene:	LOC100150651 / 100150651	-ID:	-	Length:	799	Species:	Danio rerio

Alignment Length:	800	Identity:	525/800 - (65%)
Similarity:	619/800 - (77%)	Gaps:	43/800 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    26 LLVLLWA--LGARGQGSPQQGTIVGMRLASCNKSCGTNPDGIIFVSEGSTVNLRLYGYSLGNISS 88
            |::.||:  .|::.:.......|:||||...:|...|..||||.|:|.|.:.||.||..:.|.:.
Zfish    14 LILFLWSRVCGSKAESLGSDSRILGMRLERSDKPAMTTEDGIIQVTEESDIQLRFYGLQISNDTW 78

Human    89 NLISFTEVDDAETLHKSTSCLELTKDLVVQQLVNVSRGNTSGVLVVLTKFLRRSESMKLYALCTR 153
            ..|.|.|..:..:...:.:|.:.|||:.|:..::|:...|||||.|..|.||:|||.:.|.||.|
Zfish    79 AQIKFMEQGEDSSSDSNRTCADFTKDISVRTSMSVNSLGTSGVLGVKIKPLRKSESQRDYGLCIR 143

Human   154 AQPDGPWLKWTDKDSLLFMVEEPGRFLPLWLHILLITVLLVLSGIFSGLNLGLMALDPMELRIVQ 218
              .:|.|....:.|..|.:|||....||:|..::||..||||||:||||||||||||||||||||
Zfish   144 --QNGRWFSLGEHDGRLRVVEEKKSMLPIWFQVILICCLLVLSGMFSGLNLGLMALDPMELRIVQ 206

Human   219 NCGTEKERRYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGLMAVASSTIGIVIFG 283
            :|||:||::||||||||||||||||||||||||||||:||||||:||||||.||.:|||||||||
Zfish   207 SCGTDKEKKYARKIEPIRRKGNYLLCSLLLGNVLVNTTLTILLDDLIGSGLGAVVASTIGIVIFG 271

Human   284 EILPQALCSRHGLAVGANTILLTKFFMLLTFPLSFPISKLLDFFLGQEIRTVYNREKLMEMLKVT 348
            ||:|||||||||||||||||.:|||||.||||||:|||||||..|||||.||||||||:.|||||
Zfish   272 EIVPQALCSRHGLAVGANTIHVTKFFMFLTFPLSYPISKLLDCVLGQEIGTVYNREKLVGMLKVT 336

Human   349 EPYNDLVKEELNMIQGALELRTKTVEDIMTQLQDCFMIRSDAILDFNTMSEIMESGYTRIPVFED 413
            ||||||||||:||||||||||||||||:||.|.:||||.|||:|||||||||||||||||||:||
Zfish   337 EPYNDLVKEEMNMIQGALELRTKTVEDVMTPLNNCFMINSDAVLDFNTMSEIMESGYTRIPVYED 401

Human   414 EQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKV 478
            |::||||||:|||||||||||||.|||||:||||||||||||||||:||||||||||||||||||
Zfish   402 ERTNIVDILFVKDLAFVDPDDCTTLKTITKFYNHPVHFVFHDTKLDSMLEEFKKGKSHLAIVQKV 466

Human   479 NNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVS-EKNKRDFSAFKDADNEL 542
            |||||||||||||||||||||||||||.|||||||:|||||:||:|: .||||||||||. ::|.
Zfish   467 NNEGEGDPFYEVLGLVTLEDVIEEIIKCEILDESDLYTDNRNRKKVAHNKNKRDFSAFKH-ESES 530

Human   543 KVKISPQLLLAAHRFLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNK 607
            |||||||||||||||||||||.||||.||||||||:||:||||||:||:|::|..:.||||.|.|
Zfish   531 KVKISPQLLLAAHRFLATEVSLFSPSQISEKILLRILKHPDVIQEIKFNENDKKSSHHYLYLRGK 595

Human   608 PADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTSVPSVPSVQVGCPPG---KRNSLLCWL 669
            |.|||||||||:||||||.||||||||.||:||.||| |.|::  |.|..|..   ||.||....
Zfish   596 PVDYFILILQGRVEVEAGNENMKFETGPFSFYGVMAL-SAPTL--VSVSRPRHLSLKRCSLFSRF 657

Human   670 TD-RSPAHPTPLSRSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRALVDLQYIKIT 733
            .: |||:|.:.|:|||||||.||.:   :.:::||:.|..||.|.||..||:||||.|||::|||
Zfish   658 PEFRSPSHISGLNRSASLSYTDRPE---SQSVSGSNTQLSSSALPQYTPDFNVRALADLQFVKIT 719

Human   734 RQQYQNGLLASRMENSPQFP---------IDGCTT--------HMENLAEKSELPVVDETTTLLN 781
            |.||||||:|||:::|||.|         :|..|:        :|..||:.|     ||||:|||
Zfish   720 RSQYQNGLMASRLDSSPQSPDSGHGRQVDMDNSTSSAPHRTSENMLTLADAS-----DETTSLLN 779

Human   782 ERNS-----LLHKASHENAI 796
            |:||     ..|...:|:||
Zfish   780 EQNSQPARQANHNTHNESAI 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNNM4	XP_005263971.1	DUF21	196..358	CDD:279876	141/161 (88%)
		CBS	373..500	CDD:223591	113/126 (90%)
		CBS_pair_CorC_HlyC_assoc	382..502	CDD:239963	109/119 (92%)
LOC100150651	XP_021332085.1	CorC_HlyC	170..>501	CDD:332085	288/330 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194330355
Domainoid	1	1.000	312	1.000	Domainoid score	I7057
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	962	1.000	Inparanoid score	I2489
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG44109
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		oto45793
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	LDO	PTHR12064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1902
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800