DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNNM4 and cnnm4

DIOPT Version :9

Sequence 1:	XP_005263971.1	Gene:	CNNM4 / 26504	HGNCID:	105	Length:	796	Species:	Homo sapiens
Sequence 2:	NP_001090672.1	Gene:	cnnm4 / 100036645	XenbaseID:	XB-GENE-999369	Length:	769	Species:	Xenopus tropicalis

Alignment Length:	787	Identity:	495/787 - (62%)
Similarity:	607/787 - (77%)	Gaps:	38/787 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    20 LLAAPVLLVLLWALG--ARGQGSP---QQGTIVGMRLASCNKSCGTNPDGIIFVSEGSTVNLRLY 79
            :|...:.|:||..|.  |....||   :...|:|.||...::....:|||.:.|.|||.:.||:|
Frog    11 VLGCALSLLLLPPLSRCAARTDSPLPEELPLILGFRLERSDRHAALSPDGELEVVEGSRLELRVY 75

Human    80 GYSLGNISSNLISFTEVDDAETLHKSTSCLELTKDLVVQQLVNVSR---GNTSGVLVVLTKF-LR 140
            |..|...|.::::|||.....  ..:.||||.::|||:.:| |||.   |.....:|.|... ||
Frog    76 GLHLREDSGHILAFTEYSPGS--QDNRSCLEDSRDLVLTRL-NVSDDGFGAAGAAIVRLDVLPLR 137

Human   141 RSESMKLYALCTRAQPDGPWLKWTDKDSLLFMVEEPGRFLPLWLHILLITVLLVLSGIFSGLNLG 205
            :|:|.::|.|||...|..||...|..|..|.::||....||:||...:|.|||.|||||||||||
Frog   138 KSQSSRVYVLCTSRGPGLPWKLHTGPDGRLRVLEEEKPLLPIWLQACIIAVLLTLSGIFSGLNLG 202

Human   206 LMALDPMELRIVQNCGTEKERRYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGLM 270
            ||||||||||:||.||||||:|||.||||:||||||||||||||||||||:||.|||.||||||.
Frog   203 LMALDPMELRVVQRCGTEKEKRYASKIEPVRRKGNYLLCSLLLGNVLVNTTLTALLDELIGSGLA 267

Human   271 AVASSTIGIVIFGEILPQALCSRHGLAVGANTILLTKFFMLLTFPLSFPISKLLDFFLGQEIRTV 335
            ||.:||.|||:.|||:||||||||||||||||:.||:.|||||||:::|:|:|||..|||||.||
Frog   268 AVLASTTGIVVLGEIVPQALCSRHGLAVGANTLWLTRIFMLLTFPVAYPVSRLLDCALGQEIGTV 332

Human   336 YNREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLQDCFMIRSDAILDFNTMSEI 400
            ||||||:|||||||||:.:|:||:|:||||||||||||||:||:::||||:.|||:|||||||.|
Frog   333 YNREKLLEMLKVTEPYSGIVREEMNIIQGALELRTKTVEDVMTKVEDCFMLPSDAVLDFNTMSSI 397

Human   401 MESGYTRIPVFEDEQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEF 465
            ||||||||||:|:|:|||||||||||||||||||||||.||||||:||:||||.||||||:||||
Frog   398 MESGYTRIPVYENERSNIVDILYVKDLAFVDPDDCTPLSTITRFYSHPLHFVFSDTKLDAVLEEF 462

Human   466 KKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVSEK-NK 529
            ||||||||||||||:||||||||||:||||||||||||||||||||||:||||||:|||..: ::
Frog   463 KKGKSHLAIVQKVNSEGEGDPFYEVMGLVTLEDVIEEIIKSEILDESDLYTDNRSKKRVKRRQDR 527

Human   530 RDFSAFKDADNELKVKISPQLLLAAHRFLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHN 594
            :|||.||||||||:|||||||||||||||:|||..|:|:|:|||.||||||||||:|||.|:|.:
Frog   528 KDFSVFKDADNELRVKISPQLLLAAHRFLSTEVPLFAPALVSEKTLLRLLKYPDVVQELHFNEDD 592

Human   595 KYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTSVPSVPSVQVGCPP 659
            |..:.::||.|:|.||||||||||||||||||||||||:|||||||.||: :.||...:
Frog   593 KKASENFLYQRSKIADYFILILQGKVEVEAGKENMKFESGAFSYYGVMAI-NTPSAAEL------ 650

Human   660 GKRNSLLCWLTDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRAL 724
                        |||:|.:.|:||.|||..:|:| |.::|::||:.|.  |...||::|||||||
Frog   651 ------------RSPSHMSSLNRSISLSCHERSD-SISSTISGSNTQL--SAQAQYMADFSVRAL 700

Human   725 VDLQYIKITRQQYQNGLLASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHK 789
            .|||::||||:|||..|::||:::|||.|..|.......|:|:||: :.||||:|||:||| .|.
Frog   701 GDLQFVKITREQYQGALMSSRLDSSPQSPEGGTRKPDSTLSERSEV-LEDETTSLLNQRNS-QHS 763

Human   790 ASHENAI 796
            ..| ||:
Frog   764 LQH-NAV 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNNM4	XP_005263971.1	DUF21	196..358	CDD:279876	129/161 (80%)
		CBS	373..500	CDD:223591	108/126 (86%)
		CBS_pair_CorC_HlyC_assoc	382..502	CDD:239963	105/119 (88%)
cnnm4	NP_001090672.1	CorC_HlyC	179..>510	CDD:332085	271/330 (82%)
cnnm4	NP_001090672.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..769		25/54 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	312	1.000	Domainoid score	I8805
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75662
Inparanoid	1	1.050	921	1.000	Inparanoid score	I3561
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG44109
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		oto148191
Panther	1	1.100	-	-	LDO	PTHR12064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1902
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110