DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLEK2 and sif

DIOPT Version :9

Sequence 1:	NP_057529.1	Gene:	PLEK2 / 26499	HGNCID:	19238	Length:	353	Species:	Homo sapiens
Sequence 2:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	100/472 - (21%)
Similarity:	159/472 - (33%)	Gaps:	164/472 - (34%)

- Green bases have known domain annotations that are detailed below.

Human     5 VLKEGF------LVKRGHIV-----HNWKARWFILRQNTLVYYKLEG--GRRV-TPPKGRILLDG 55
            |.|.||      |:::.|.:     ..||..|..|:..||::|..:.  ||.| ..||..|::||
  Fly   862 VRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDG 926

Human    56 CTITCPCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAI------HAGQPGKVQQL 114
             .|..|..|:..|..:..|.|.....|..:|..:.|.:.|...|..|.      |.|:.|.:..|
  Fly   927 -AIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLL 990

Human   115 --------------HSLRNSFKLPPHI-----SLHRI----------VDKMHDSNTGIR------ 144
                          |.|::..:|...:     :.|:|          ::::|.....:|
  Fly   991 QEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASL 1055

Human   145 ---SSPNMEQGSTY-----KKTF--LGSSLVDWLISNSFTASRLEAVTLA-SMLMEENFLRPVGV 198
               ..||.:...|:     |.|.  ||          .||.|...|...| |..:..|.|...|.
  Fly  1056 QSGELPNPKSLLTHVSRPTKNTLNKLG----------VFTVSSFHAFICARSPSLLNNLLAGRGA 1110

Human   199 -----------------RSMGAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLSTVELSG 246
                             ||| .:.|.|..|:         ||      |::..:. :.|||.|..
  Fly  1111 TKRRPPMLSRSNSGSSRRSM-QMNSRDEPEK---------TF------KVAMPDN-AYSTVYLRD 1158

Human   247 TVVKQGYLAKQGHKRKNWKVRRFV---LRKDPAFLHYYDPSKE---EN----------------- 288
            .:..:.:||....:|....:..||   .|:|....:|:.|.:.   ||
  Fly  1159 AMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQ 1223

Human   289 --------RPVGGFSLRGSL-------------VSALED------NGVPTGVKGNVQGNLFKVIT 326
                    ..:.|||:...|             ||.:||      ||:   :||:....:...|.
  Fly  1224 VELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGI---IKGDEIMVINGAIV 1285

Human   327 KDDTHYYIQASSKAERA 343
            .|....|:::..:.|::
  Fly  1286 SDLDMMYLESVLQEEQS 1302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLEK2	NP_057529.1	PH1_Pleckstrin_2	3..113	CDD:270113	36/127 (28%)
		PH	5..95	CDD:278594	30/103 (29%)
		DEP_PLEK2	128..236	CDD:239891	29/151 (19%)
		PH2_Pleckstrin_2	242..353	CDD:270114	29/152 (19%)
		PH	248..352	CDD:278594	27/146 (18%)
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	35/123 (28%)
		PH	873..974	CDD:278594	29/101 (29%)
		TIAM1_RBD	1141..1219	CDD:176413	18/84 (21%)
		PDZ_signaling	1221..1308	CDD:238492	16/85 (19%)
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910