DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KAT2A and Brd8

DIOPT Version :9

Sequence 1:	NP_001363156.1	Gene:	KAT2A / 2648	HGNCID:	4201	Length:	838	Species:	Homo sapiens
Sequence 2:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster

Alignment Length:	246	Identity:	61/246 - (24%)
Similarity:	92/246 - (37%)	Gaps:	65/246 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     8 PTP---APAAQPRPLQSPAPAPTPT------PAPSPASAPIPT---PTPA-----PAPAPAAAPA 55
            |||   ||||......:.|.|||.|      |:.:.|:.|:.|   ||.|     |...|.|:.|
  Fly   246 PTPGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSRPITGPPASEA 310

Human    56 GSTGTGGPGVGSGGAGSGGDPARPGLSQ--QQRASQRKAQVRG---LPRAKKLEKLGVFSACKAN 115
            .:|.|         .......|.|.||.  ::..:..||...|   .|.....::.||..|
  Fly   311 STTPT---------LERSPSQAAPTLSMLLEKNMAAAKANESGSLVKPEGSGNQEQGVDEA---- 362

Human   116 ETCKCNGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVE 180
             |....|       ||...:.....|.|.|:.::.:..:.|....:.:|.:|||      :.:|:
  Fly   363 -TSSAAG-------TADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEI------LKNVD 413

Human   181 NLFMSVHKEEDTDTKQVYFYLFKL--LRKCILQMTRPVVEGSLGSPPFEKP 229
            ::..|    ...|..:|..:..||  |::          |.|..||..:||
  Fly   414 DVVAS----PSNDKAEVIDFEDKLDALKR----------EQSKSSPASDKP 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KAT2A	NP_001363156.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99		32/112 (29%)
		PCAF_N	89..335	CDD:368925	32/146 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..434
		COG5076	492..833	CDD:227408
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	579..581
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	586..592
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	617..620
		Loop 3. /evidence=ECO:0000269\|PubMed:29211711	639..648
		Bromo_gcn5_like	733..832	CDD:99941
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408
		PHA03249	402..>582	CDD:223023	17/69 (25%)
		Bromo_brd8_like	729..833	CDD:99939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900