DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KAT2A and polybromo

DIOPT Version :9

Sequence 1:	NP_001363156.1	Gene:	KAT2A / 2648	HGNCID:	4201	Length:	838	Species:	Homo sapiens
Sequence 2:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster

Alignment Length:	829	Identity:	167/829 - (20%)
Similarity:	268/829 - (32%)	Gaps:	304/829 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    79 PGLSQQQRA----------SQRKAQVRGL----PRAKKLEKLGVFSACKANETCKCNGWKNPKPP 129
            ||.|:.|.|          .||..:..||    |||:::.:
  Fly   131 PGSSEHQDAVSLWQHIHSQRQRIMEANGLAEEEPRARRMSR------------------------ 171

Human   130 TAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVENLFMSVHKEEDTDT 194
            ...||             .|...|..|      ..::||.|:       .|.||.||....|...
  Fly   172 QVRRM-------------TSSTEPGGD------GATDDEYNQ-------YEELFASVMTATDPVG 210

Human   195 KQVYFYLFKLL-RKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQYK-----FSHLAPRERQT 253
            .::...:|:|| .|.|......|:|..:.             |..:..|     :|.||..||
  Fly   211 DRLMHRMFQLLPSKKIYPDYYDVIEHPID-------------LRLIATKIQMNAYSSLAEMER-- 260

Human   254 MFELSKMFLLCLNYWKLETPAQFRQRSQAEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFG 318
              :|.:|                                |:..|..:.|.|        ..:...
  Fly   261 --DLLQM--------------------------------TKNACLFNEPGS--------QIYKDA 283

Human   319 RSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIYGAN---------SPI 374
            :||.| |||..|.:|    .:.|.||....::|    ....::.|:||:..::         .|:
  Fly   284 KSLKR-IFTQRRIEL----EMGKGKLAKRVKSL----SSAAIAALKEEVDSSDDEETSKKGEGPM 339

Human   375 W--------------ESGFTMPP--------------SEGTQLVPRPASVSAAVVPSTPIFSPSM 411
            |              ..|.|.||              .|..:|:.||.|:|..   .|.:   ..
  Fly   340 WALFDHLYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQI---HTKL---KK 398

Human   412 GGGSNSS-------LSLDSAGAEPMPGEKRTLP-ENLTLEDA-KRLRVMGDIPMELVNEVMLTIT 467
            |..:|.|       |.||:|        |:..| .:.|.:|| |.|::|.   .:||.|.:...:
  Fly   399 GDYANISDLTADLYLMLDNA--------KKAFPTSHRTHKDALKMLKLMN---AKLVEESLEEGS 452

Human   468 D----PAAMLGPETSLLSANAARDETA--RLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNV 526
            |    .|..:..|...:|....:.:..  |:.........|...||.:||:||      :.:...
  Fly   453 DLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNR------IAINAA 511

Human   527 FSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYG 591
            ...::..:.|..:...:.:.:...:.:.|..|       :::|                   .|.
  Fly   512 IKKKILSIQKYLVDYSLGNRRPIEMFMEKPPR-------KIYP-------------------DYY 550

Human   592 THLMNHLKEYHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKD----YEGATLME 652
            ..:.|.:....|:|||     ..|.||    ..:....|.::..|....|.::    ||.|.::|
  Fly   551 DIIQNPIDMNTIEHNI-----RTDRYA----AVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILE 606

Human   653 CELNPRIPYTELSHIIKKQKEVIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPG------ 711
            ..||.::                             |.:|||:   ||.:.....|..|
  Fly   607 RALNEKL-----------------------------KEFPGLT---EGKKSQQKYSKVGRKLKTA 639

Human   712 -IRETGWKPLGKEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPID 775
             |.|..|               |.|.|:|...........:..|.:...|||.||||::||.|||
  Fly   640 VITERLW---------------QFYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPID 689

Human   776 LKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEK 824
            :..:.::|:...|.|.....||...::.|..:||.|||:..:.|..|::
  Fly   690 MDRIAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQ 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KAT2A	NP_001363156.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99		9/33 (27%)
		PCAF_N	89..335	CDD:368925	49/255 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..434		7/33 (21%)
		COG5076	492..833	CDD:227408	70/344 (20%)
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	579..581		0/1 (0%)
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	586..592		1/5 (20%)
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	617..620		2/2 (100%)
		Loop 3. /evidence=ECO:0000269\|PubMed:29211711	639..648		3/12 (25%)
		Bromo_gcn5_like	733..832	CDD:99941	30/92 (33%)
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	7/26 (27%)
		Bromo_polybromo_II	191..294	CDD:99948	34/167 (20%)
		Bromo_polybromo_III	335..443	CDD:99951	28/124 (23%)
		Bromo_polybromo_IV	512..613	CDD:99949	22/135 (16%)
		Bromo_polybromo_V	641..733	CDD:99946	31/106 (29%)
		Bromo_polybromo_VI	758..867	CDD:99956
		BAH_polybromo	921..1040	CDD:240068
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box	1320..1375	CDD:238037
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900