Protein Alignment KAT2A and Gcn5

DIOPT Version :10

• Sequence 1: NP_001363156.1
• Gene: KAT2A / 2648
• HGNCID: 4201
• Length: 838
• Species: Homo sapiens
• Sequence 2: NP_648586.2
• Gene: Gcn5 / 39431
• FlyBaseID: FBgn0020388
• Length: 813
• Species: Drosophila melanogaster
• Alignment Length: 809
• Identity: 385/809 - (47%)
• Similarity: 534/809 - (66%)
• Gaps: 45/809 - (5%)

Human    49 APAAAPAGSTGTGG----PGVGSGGAGSGGDPARPGLSQQ--QRASQRKAQVRGLPRAKKLEKLG 107
            |..||.||::|..|    ||.|...:|:|..||. |..|.  ||..|||.:|..||..:||.||.
  Fly    31 ANGAATAGASGAAGSAQNPGHGGAASGAGSVPAE-GTRQNSLQRIQQRKQKVFNLPVPQKLAKLS 94

Human   108 VFSACKANETCKCNGWKNPKPPTAPRMDLQQP-AANLSELCR--SCEHPLADHVSHLENVSEDEI 169
            ::|||: :|.|:|.|||.|:...  ..|::.. ....:|.||  ||.|.|..|::||:|:|...:
  Fly    95 MYSACQ-SEGCRCTGWKTPQENR--HRDVESSYCPEFNEECRNTSCRHSLRSHIAHLDNISSSSM 156

Human   170 NRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQG 234
            |.|||.::|:||||||:.:.||.|||:||.|||:|||:|:|...:.|:.|.||.||||.|.|.:.
  Fly   157 NELLGAIIDMENLFMSMQRVEDEDTKKVYQYLFRLLRQCVLTRQQAVIRGPLGDPPFETPCITKA 221

Human   235 VLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQAEDVATYKVNYTRWLCYC 299
            ||:.|.||::||:..|.|||.|::|.||..||::..|:|:..|.....||.:.||:||||||.:|
  Fly   222 VLSLVFYKYNHLSTPELQTMTEVAKTFLNFLNHYNFESPSTRRGDLTHEDASNYKINYTRWLVFC 286

Human   300 HVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLE 364
            |||..|:||.:.||:.||||:|||::|....:||.:|...|:|:. ||.:..|:|..||||..|.
  Fly   287 HVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQLKKKCISERDRF-PEDKRSIITLMPKFLETLR 350

Human   365 EEIYGANSPIWESGFTMPPSEGTQLVPRPASVSAAVVPSTPIFSPSMGGGSNSSLSLDSAGAEPM 429
            .|:...:||||::.:.  ||....:..|..:...|.||..| .:.|:||...:|:      .||:
  Fly   351 AELLKDDSPIWDTSYR--PSNSFVIQQRKRNQEVANVPIGP-SAASIGGNKRTSV------GEPL 406

Human   430 PGEKRTLPENLTLEDAKRLRVMGDIPMELVNEVMLTI-----TDPAAMLGPETSLLSANAARDET 489
              .||...|......::.|   .|:|.::|...|.::     |:.|.:|.|      .|.:|||.
  Fly   407 --HKRIKKEPTDRPSSENL---DDLPADVVMRAMKSVSESKTTNKAEILFP------VNVSRDEN 460

Human   490 ARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALI 554
            .:.||::..|||||:|||||...:::.:|||:|||.||::|||.||:|||::||||.||||||||
  Fly   461 VKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPEMPREYISQLVFDTKHKTLALI 525

Human   555 KDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHNILYFLTYADEYAI 619
            |:.:.|||||||.||:||||||||||||.:|||||||||||||||:|.|:..|.:.||:||..||
  Fly   526 KENQPIGGICFRPFPSQGFTEIVFCAVTMSEQVKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAI 590

Human   620 GYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEVIIKKLIERKQ 684
            |||||||||||||:.:..|.||||:|:.||||.|||:|.|..|:...:|:.|.| |:|:||.::.
  Fly   591 GYFKKQGFSKDIKLARPVYAGYIKEYDSATLMHCELHPSIVNTQFIAVIRSQSE-ILKELIAQRH 654

Human   685 AQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKG-----KELKDPDQLYTTLKNLLAQ 744
            .:::||.|||:|||||:..|||||:||:||.||||..:...     :|..||::|.|:..::|..
  Fly   655 NEVQKVRPGLTCFKEGLPVIPVESIPGLREIGWKPQNRPARSSRPLEESTDPEKLATSFASVLQS 719

Human   745 IKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYN 809
            ::.|.:||||:.||..:|.||||:.|::|:|||||.|||:..||.||:||:||:.|:.:|||.||
  Fly   720 VRQHTTAWPFLRPVTAAEVPDYYDHIKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYN 784

Human   810 PPDSEYCRCASALEKFFYFKLKEGGLIDK 838
            .||:||.|||::||::|..|::|.||.||
  Fly   785 SPDTEYYRCANSLERYFQTKMRELGLWDK 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KAT2A	NP_001363156.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..99		23/55 (42%)
		PCAF_N	86..335	CDD:461923	119/251 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	407..434		6/26 (23%)
		COG5076	492..833	CDD:227408	198/345 (57%)
		Loop 3. /evidence=ECO:0000269|PubMed:29211711	639..648		5/8 (63%)
		Bromo_gcn5_like	733..832	CDD:99941	50/98 (51%)
Gcn5	NP_648586.2	PCAF_N	73..320	CDD:461923	117/249 (47%)
		COG5076	451..807	CDD:227408	203/362 (56%)
		Bromo_gcn5_like	708..808	CDD:99941	50/99 (51%)