DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX6 and ey

DIOPT Version :9

Sequence 1:	XP_011516823.1	Gene:	LHX6 / 26468	HGNCID:	21735	Length:	407	Species:	Homo sapiens
Sequence 2:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster

Alignment Length:	336	Identity:	69/336 - (20%)
Similarity:	111/336 - (33%)	Gaps:	122/336 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    28 QVMAQPGSGCKATTRCLEGTAP---------PAMAQSDAEALAGALDKD------EGQASPCTPS 77
            |..|.||....|....|.|.:|         |.:...:.:||.....:.      .|...|.:.|
  Fly   311 QHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLS 375

Human    78 TPSVCSPPSAAS-----SVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQN 137
            ...:.|.|:.||     |.||...::.....:|.|                       .|:..|.
  Fly   376 EIPISSAPNIASVTAYASGPSLAHSLSPPNDIESL-----------------------ASIGHQR 417

Human   138 SCYIKNKEIFCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFG 202
            :|.:..::|..|.:.          .|.|   ||                      :..:||
  Fly   418 NCPVATEDIHLKKEL----------DGHQ---SD----------------------ETGSGE--- 444

Human   203 LVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGA--VPSEQDSQ-----PKPAKRARTSFTAEQL 260
                                  .||.||    ||  :.:.:|.|     .:..:|.|||||.:|:
  Fly   445 ----------------------GENSNG----GASNIGNTEDDQARLILKRKLQRNRTSFTNDQI 483

Human   261 QVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRA--------RHKKHTPQHPVPPSGA 317
            ..::.:|.:.:.||....::||...||....|||||.|.||        |:::.||......:.:
  Fly   484 DSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATS 548

Human   318 PPSRLPSALSD 328
            ..:...::|:|
  Fly   549 SSTSATASLTD 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX6	XP_011516823.1	LIM1_Lhx6	99..152	CDD:188766	7/52 (13%)
		LIM2_Lhx6	160..214	CDD:188768	6/53 (11%)
		Homeobox	252..304	CDD:278475	22/59 (37%)
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	21/51 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940