Protein Alignment GCK and HXK2

DIOPT Version :10

• Sequence 1: NP_277042.1
• Gene: GCK / 2645
• HGNCID: 4195
• Length: 466
• Species: Homo sapiens
• Sequence 2: NP_011261.1
• Gene: HXK2 / 852639
• SGDID: S000003222
• Length: 486
• Species: Saccharomyces cerevisiae
• Alignment Length: 486
• Identity: 151/486 - (31%)
• Similarity: 256/486 - (52%)
• Gaps: 59/486 - (12%)

Human     8 SQAQTALTLVEQILAE-----FQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTP 67
            |.|.....|::||  |     |.:..|.|:.|.:....|:::||   :.:..::.|:|.:|...|
Yeast    15 SMADVPKELMQQI--ENFEKIFTVPTETLQAVTKHFISELEKGL---SKKGGNIPMIPGWVMDFP 74

Human    68 EGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAM--TGTAEMLFDYISEC 130
            .|.|.||||::||||||.||:|||:|    |..:..|....|.:| |||  |...:.|:::|::.
Yeast    75 TGKESGDFLAIDLGGTNLRVVLVKLG----GDRTFDTTQSKYRLP-DAMRTTQNPDELWEFIADS 134

Human   131 ISDFLDKH--QMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRR 193
            :..|:|:.  |...:.:|||||||||.....|::|||..|||||.....|.::||.:|:..|.:|
Yeast   135 LKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKR 199

Human   194 GDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEG-------DEGR 251
             :..::|||::|||..|:::.||.|.:.::|:|.|||.|..|.:...::|.::|       ....
Yeast   200 -NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAP 263

Human   252 MCVNTEWGAFGDSGELDEFLL---EYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDE 313
            |.:|.|:|:|.:    :..:|   :||..:||.|..||||.:||:..|.|:||::||.|:.:..:
Yeast   264 MAINCEYGSFDN----EHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQ 324

Human   314 NLLFHGEASEQLRTRGAFETRFVSQVE-------SDTGDRKQIYNILSTLGLRPSTTDCDIVRRA 371
            ..:|..:...:.......:|.:.:::|       .||.|..|     :..|:..:..:..::||.
Yeast   325 GFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQ-----NEFGINTTVQERKLIRRL 384

Human   372 CESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL----- 431
            .|.:..|||.:...|:|.:..:.......      :..|||||..:|.|||:...:::.:
Yeast   385 SELIGARAARLSVCGIAAICQKRGYKTGH------IAADGSVYNRYPGFKEKAANALKDIYGWTQ 443

Human   432 --TPSCEITFIESEEGSGRGAALVSAVACKK 460
              .....|..:.:|:|||.|||:::|:|.|:
Yeast   444 TSLDDYPIKIVPAEDGSGAGAAVIAALAQKR 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCK	NP_277042.1	ASKHA_NBD_HK4_meta	17..459	CDD:466942	147/474 (31%)
HXK2	NP_011261.1	ASKHA_NBD_HK1-2_fungi	38..458	CDD:466937	134/443 (30%)