Protein Alignment GCK and HXK1

DIOPT Version :10

• Sequence 1: NP_277042.1
• Gene: GCK / 2645
• HGNCID: 4195
• Length: 466
• Species: Homo sapiens
• Sequence 2: NP_116711.3
• Gene: HXK1 / 850614
• SGDID: S000001949
• Length: 485
• Species: Saccharomyces cerevisiae
• Alignment Length: 464
• Identity: 156/464 - (33%)
• Similarity: 259/464 - (55%)
• Gaps: 37/464 - (7%)

Human    17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLG 81
            :.|:...|.:..|.|:||::....|:::||   |.:..::.|:|.:|...|.|.|.|::|::|||
Yeast    27 IHQLEDMFTVDSETLRKVVKHFIDELNKGL---TKKGGNIPMIPGWVMEFPTGKESGNYLAIDLG 88

Human    82 GTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGT-AEMLFDYISECISDFLDKHQMKHKK- 144
            |||.||:|||:    .|..:..|....|.:|.|..|.. .|.|:.:|::.:.||:.:.::.:.|
Yeast    89 GTNLRVVLVKL----SGNHTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKDFMVEQELLNTKD 149

Human   145 -LPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTV 208
             ||||||||:|.....|::|||..|||||.....||::||.||::.|.:| :..:::||::||||
Yeast   150 TLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKR-ELPIEIVALINDTV 213

Human   209 ATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEG-------DEGRMCVNTEWGAFGDSGE 266
            .|:|:.||.|.:.::|:|.|||.|..:.:.:.::|.:||       ....|.:|.|:|:| |:..
Yeast   214 GTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIPSNSPMAINCEYGSF-DNEH 277

Human   267 LDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAF 331
            |.....:||..|||.|..||||.:||:..|.|:|||:|||||.|.::.|:...:...:|:.....
Yeast   278 LVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIM 342

Human   332 ETRFVSQVESD----TGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVIN 392
            :|.:.:::|.|    ..|...|:.  ...|::.:..:..::||.||.:.||||.:...|:|.:..
Yeast   343 DTSYPARIEDDPFENLEDTDDIFQ--KDFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQ 405

Human   393 RMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL------TPSCEITFIESEEGSGRGAA 451
            :.......      :..|||||..:|.|||.....:|.:      .....||.:.:|:|||.|||
Yeast   406 KRGYKTGH------IAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAA 464

Human   452 LVSAVACKK 460
            :::|::.|:
Yeast   465 VIAALSEKR 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCK	NP_277042.1	ASKHA_NBD_HK4_meta	17..459	CDD:466942	155/461 (34%)
HXK1	NP_116711.3	ASKHA_NBD_HK1-2_fungi	38..471	CDD:466937	153/449 (34%)