DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCK and Hex-A

DIOPT Version :9

Sequence 1:	NP_277042.1	Gene:	GCK / 2645	HGNCID:	4195	Length:	466	Species:	Homo sapiens
Sequence 2:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	217/474 - (45%)
Similarity:	312/474 - (65%)	Gaps:	23/474 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     6 TRSQAQTAL-------TLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYV 63
            |.|..|.||       .:|.::..:..|.:|.::::..|:..|:.|||..:||.:|:||...|||
  Fly    77 THSPQQIALLSAAEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYV 141

Human    64 RSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYIS 128
            :..|.|:|.|.||:||||||||||:|:.:.|..:.|    .:.::|:||:..|.|:...|||:|:
  Fly   142 QDLPNGNERGKFLALDLGGTNFRVLLIHLQENNDFQ----MESRIYAIPQHIMIGSGTQLFDHIA 202

Human   129 ECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRR 193
            ||:|:|:.:|.:..::||||||||||:|...:.||:|..|||||..:|....:||.||:|||.||
  Fly   203 ECLSNFMAEHNVYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARR 267

Human   194 GDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR---MCVN 255
            ||.::||.|::|||..|::||.:::|.|::|:|||||.||||||.::..||...::.|   :.:|
  Fly   268 GDVQIDVCAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLIN 332

Human   256 TEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGE 320
            ||||||||:|.||....|:||.:|..|.|||:|.:||:|.|.||||||||||:::....:||:|:
  Fly   333 TEWGAFGDNGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQ 397

Human   321 ASEQLRTRGAFETRFVSQVESD-TGDRKQIYNILSTLGLRPSTT-DCDIVRRACESVSTRAAHMC 383
            .||.|.|||.|.|::||::|:| .|:......:|..|||..:|. ||..||..||.||.||||:.
  Fly   398 DSEVLNTRGLFFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLV 462

Human   384 SAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL-TPSCEITFIESEEGSG 447
            |||:|.:||:|      |...:|||||||||:.||.|.......:.:| .|......:.||:|||
  Fly   463 SAGIATLINKM------DEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLSEDGSG 521

Human   448 RGAALVSAVACKKACMLGQ 466
            ||||||:||||::..:.|:
  Fly   522 RGAALVAAVACREDILNGK 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCK	NP_277042.1	COG5026	17..459	CDD:227359	210/447 (47%)
GCK	NP_277042.1	Hexokinase_1	17..216	CDD:376323	89/198 (45%)
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	89/198 (45%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	116/239 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I2536
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1838
Isobase	1	0.950	-	0	Normalized mean entropy	S1223
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm8559
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2154
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.920