Protein Alignment GCK and Gck

DIOPT Version :10

• Sequence 1: NP_277042.1
• Gene: GCK / 2645
• HGNCID: 4195
• Length: 466
• Species: Homo sapiens
• Sequence 2: NP_001257778.1
• Gene: Gck / 24385
• RGDID: 2670
• Length: 498
• Species: Rattus norvegicus
• Alignment Length: 516
• Identity: 408/516 - (79%)
• Similarity: 421/516 - (81%)
• Gaps: 68/516 - (13%)

Human     1 MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETH----------EEAS 55
            ||||.||..|| .|||                 ...:.........|..||          |:|:
  Rat     1 MAMDTTRCGAQ-LLTL-----------------GTNKCTNACSLLCRAGTHNGHMNPRCRTEQAA 47

Human    56 VKMLPT---------YV--RSTP------------------EG-----------SEVGDFLSLDL 80
            ...|||         :|  |:.|                  ||           .||||||||||
  Rat    48 ATQLPTCRVQLLLNYHVEGRADPGRVPAAGGRPEEGDEPDAEGDGPWPEAGDPRGEVGDFLSLDL 112

Human    81 GGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKL 145
            ||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   113 GGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKL 177

Human   146 PLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVAT 210
            ||||||||||||||:|||||||||||||||||||||:||||||||||||||||||||||||||||
  Rat   178 PLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVAT 242

Human   211 MISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYD 275
            ||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   243 MISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYD 307

Human   276 RLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVE 340
            |:|||||||||||||||:|||||||||||||||:|||||||||||||||||||||||||||||||
  Rat   308 RMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVE 372

Human   341 SDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRI 405
            ||:||||||:|||||||||||.|||||||||||||||||||||||||||||||||||||||||||
  Rat   373 SDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRI 437

Human   406 TVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 466
            ||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||.|
  Rat   438 TVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCK	NP_277042.1	ASKHA_NBD_HK4_meta	17..459	CDD:466942	389/491 (79%)
Gck	NP_001257778.1	ASKHA_ATPase-like	100..491	CDD:483947	376/390 (96%)