Protein Alignment Nbea and mv

DIOPT Version :10

• Sequence 1: XP_036019004.1
• Gene: Nbea / 26422
• MGIID: 1347075
• Length: 2968
• Species: Mus musculus
• Sequence 2: NP_647681.2
• Gene: mv / 38259
• FlyBaseID: FBgn0288310
• Length: 3535
• Species: Drosophila melanogaster
• Alignment Length: 3488
• Identity: 711/3488 - (20%)
• Similarity: 1167/3488 - (33%)
• Gaps: 1199/3488 - (34%)

Mouse   258 LNNINVDKDKPYLYCF----RTSKGVGYSA----HFVGNCLIVT-SLKSKGKGFQHCV------- 306
            ||.|:|   :.:..||    ..:|...:|.    |.....|.:| :|.|:.:..|..:
  Fly   358 LNQIDV---RNFDACFEVLQEAAKSTNFSTAIFLHIYKMLLRLTDNLSSQEQHLQSLMESSASTA 419

Mouse   307 --KYDFQPRKWYMISIVHIYNRWRNSEIR--------CYVNGQ-------------------LVS 342
              |....||          :.|.|:|::.        ||..|:                   |:.
  Fly   420 MPKQQQHPR----------HKRQRSSQLHCLGATSLSCYFQGKLYHLLPSLEAELQEHSVRSLLR 474

Mouse   343 YGDMAWHVNT-------------NDSYDKC---FL---------------GSSETAD--ANRVFC 374
            .|....|.|.             :.||.||   ||               |.....|  .:.||.
  Fly   475 TGSCCCHYNVRNYATCLQLATQLSSSYQKCAYKFLHYNVLHTIFVKRNPQGCPGCEDKLKSPVFH 539

Mouse   375 GQLGAVYV--FSEALN-PAQ-IFAVHQLGPGYKSTFKFKS----ESDIHLAEHHKQVLYDGKLAS 431
            ..|..:|.  :...|| ||. :|..|.....|...:...|    |..:.:...:|:::..|:...
  Fly   540 MDLLNIYKDNYKALLNTPAMLLFLKHLKHIAYLLPYDLASGILAEVALPIFRRYKELIESGESKR 604

Mouse   432 SIAFSYNAKATDAQLCLESSPKEN-------ASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGI 489
            .|     :|.|..||   .|..||       .||||     :.|.|::.:      .|.::...|
  Fly   605 KI-----SKVTPLQL---PSKLENYRALHECLSIFV-----MYLSDIRLV------KAFYNEENI 650

Mouse   490 QVLFPLFAQLDNRQLNDSQVETTVCATL------LAFLVELLKSSVAMQEQML---------GGK 539
            :.:..|        |...:::..||..:      :|||.|..:..:.:..:::         ..:
  Fly   651 RYMQDL--------LIIPELQRGVCDLIKVGIDNIAFLGENSQEQITLSRRLIQLQLNSSDRASQ 707

Mouse   540 GFLVIGYLLEKSSRVHI------TRAVLEQ---------------------------FLSFAK-- 569
            .|..:.|...|.||...      |.|.||.                           :..|||
  Fly   708 LFQALLYKCSKHSRAKFWLDESSTPAKLEGHKPADILYITALQWTLNFELLKTSQLFYNEFAKIY 772

Mouse   570 ---------------------YLDG---LSHGAPLLKQLCDHILFN----------PAIWIHTPA 600
                                 .|.|   |.||.   |.:.|.:..|          |..   |..
  Fly   773 SIPVEMLDDEDEDEVETPTSELLPGEKKLRHGD---KNIFDILKLNYNALGCFLMLPKA---TMG 831

Mouse   601 KVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSSGIAPKGLD-----GP 660
            ....|..|..:|...|::::.|.:.:    |.|..:...   .:..|.||..|...||     |.
  Fly   832 PTTSSTATTPTAGICGSSSLETLVSQ----LPLAGSTSV---SVTTAASSDYADSTLDYASVIGN 889

Mouse   661 RPSQKEIISLRAFMLLFL-----KQLILKDRGVKEDELQSILNYLLTMHEDEN------IHDVLQ 714
            ..|....::..:|:...|     :..:|.|....:....:..|.|:...|:|.      |:.:..
  Fly   890 YDSYSRDMATPSFLQQLLACEPDESTVLFDIRGSQSSKDNPSNSLILPSEEEGATADGIINKLFS 954

Mouse   715 LLVALMSEHPASMIPA--------------FDQRNGIRVIYKLLASKSESIWVQALKVLGY---- 761
            ::.:|....|.|...|              ..:.||  ...|||....|:  ..|:.:.|:
  Fly   955 IVGSLFGGSPGSGGSANSPTRANIDADFFCLYEPNG--ECKKLLLKLFEA--TMAICIKGFQNEE 1015

Mouse   762 ---FLKHLGHKRKVEIMHTHSLFTLLGERLMLHT-NTVTVTTYNTLYEIL----TEQVCTQVVHK 818
               ..|||...|.:.:.|....::..||:   |. :...:.|..||.:|.    |.|..|.||:.
  Fly  1016 VEKMQKHLRKLRAIILSHATDNWSEHGEQ---HARDNAVIQTLQTLLKIAELSSTHQEPTGVVNS 1077

Mouse   819 P-----HPEP------DSTVKIQNPMILKVVATLLKNS-----TP-------------SAELMEV 854
            |     .|.|      ..:|::.....:|:.|   |||     ||             .|:....
  Fly  1078 PSGDSQQPRPRARSFNSGSVELPRLQTVKLPA---KNSLATPPTPRRRPNSSEANAGVDADYFST 1139

Mouse   855 RRLF---LSDMIKLFSNSRE-------------------NRRCLLQC-------SVWQDWMFSLG 890
            |...   ....::|..|..|                   ...|.|..       |.|..:..|..
  Fly  1140 RASLSCAADSELELSENEHEFYLTADEGYEADGEIADLSESECELNGGVLAANESTWTPFQPSSR 1204

Mouse   891 YINPKSSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLA------ 949
            |  ......|.::::|..:...|....||...|    |.::|:...:::.  ..::||.
  Fly  1205 Y--RSHIMHQGLSQLVVQMLAELSLLCIKQPNG----WTESLTQLANRLF--VIRDYLGGPLCLL 1261

Mouse   950 KMYEEYQRQEEENIKKGKKGNVSTISGLS---------SQTAGAKGGMEI--REIEDLS----QS 999
            |.:.......:..:::.::..:..::.|:         |..|..:..:::  |.:..:|    :.
  Fly  1262 KGFAPILSCSDPRLRELQQSILELVTHLNTPEVLQCYYSILASKQPPVDLLMRHMHHISSGSLRK 1326

Mouse  1000 QSPESETDYPVSTDTRDLLMSTK-VSDDILGSSDRPGSGVHVEVH-------------------- 1043
            ..|..|.|:|:.||.:.::.|.. ||:.|          ..|.:|
  Fly  1327 AQPCMELDFPIITDGKIVVTSEPLVSEQI----------ERVRLHHQQCQTNTLFTRAACIFPVT 1381

Mouse  1044 ------------DLLVDIKAEKVEATEVKLDD-------MDLSPETLVG-GENGALVEV------ 1082
                        .|.::::.:::..:.::.:|       .||:...|:. |.|.|:|.:
  Fly  1382 QTRLWQPDGLTLSLWLELRGQQMHRSSMQFNDDETRYSGEDLTKLHLLSLGTNQAMVSIYISNNM 1446

Mouse  1083 ----ESLLDNVYSAAV---EKLQNNVHGSVGIIKKNEEKDNGPLI--TLADEKEELPNS------ 1132
                |.:..|...|.|   |:::.|. .:..:|..|.:..||..|  .|...|..|.||
  Fly  1447 QLIFELVKPNEQLAPVRVEEQIEANA-DTASVISANTQAANGGTIRQALKQTKLALLNSFGQMHL 1510

Mouse  1133 ---------STPFLFDKIPRQEEKL-LPELSSNHIIPNIQDTQVHLGVSDDLGLLAHMTASV--- 1184
                     ||...|:....|.:.| ||.....|::..:|.....:.:|..|..|...|..:
  Fly  1511 LNGHQASADSTGGYFESSAVQLQHLRLPRHKWMHLVFGLQQQADSVEISIFLDGLEQHTMRLPFR 1575

Mouse  1185 ---ELTCTSSIMEEKDFRIHT-------------TSDGVSSVSERELASST-------------- 1219
               :||           |:|:             .|.|.||.|...|..||
  Fly  1576 NLRQLT-----------RVHSFQLLALGEGQPTGRSPGSSSSSRSTLDGSTPRYALSNVILFKRR 1629

Mouse  1220 ------------KGLDYAEMTATTLETESSNSKAVPN---VDAGSIISDTERSDDGK--ESGKEI 1267
                        .|.|:.|.|    :.:.:|.|  ||   |..|.:.|    |:.|.  :..:::
  Fly  1630 LVDPLLMMNLTAMGPDFTEFT----QCQVANWK--PNYGFVSLGKLSS----SNFGNHLDCMRQL 1684

Mouse  1268 RKIQTTATTQAVQGRSSTQQDRDLRVDLGFRGMP--------------MTEEQRRQFSPGPRTTM 1318
            |:.:....| |.|.......|....:|:...|.|              .|.:.....|.|..|.:
  Fly  1685 RQARVLVYT-AQQPDLVMSYDASQELDMACYGQPHGHMLYGELQQHQAQTLQAATSLSGGLSTLL 1748

Mouse  1319 F---RIPEFKWSPMHQRLLTDLLFAL-ETDVHVWRSHSTK---SVMDFVNSNENIIFVHNTIHLI 1376
            :   ||.|...:...|.|..|||..: .:|..::.....:   |::.:|..:|.   ....:.|:
  Fly  1749 YLFARIVELTGNASTQALALDLLLQVAHSDAQLYTEFQRQDYLSLIGYVIKSEK---CSKDVQLL 1810

Mouse  1377 SQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMV--------- 1432
            ..:|:|   ||..:|.....           ::|.|.....| |.|  ..|||..|
  Fly  1811 RSIVNN---ACSQVLITRKG-----------DSINVNDNTMA-TLV--YPRLMLTVLQRYSDWHR 1858

Mouse  1433 ------DVL--VFASSL----------NFSEIEAEKNMSSGGLMRQCLRLV-------------- 1465
                  |||  :|...|          :|:..:.:|....|.|:..|...|
  Fly  1859 SGATHSDVLDMLFRCILALTRDKHPQRDFNMEQLQKCGLLGALLNLCKVYVIESPSPVQISPYAA 1923

Mouse  1466 -CCVAVRNCLECRQRQRDRGSKSSHGSS-------------KPQEA------PHSVTAASASKTP 1510
             |.|.:....          |.|...||             ||.:.      .|.....:|.:..
  Fly  1924 ECFVQILAVF----------SGSPPDSSMLDEIMKLLLLLHKPSDCYVTHDRTHFYFLLTAQQPT 1978

Mouse  1511 LEN--VPGNLSPIK--------------DPDRLLQDVDINRLRAVV---------FRD-VDDSKQ 1549
            .|.  |..|||.:.              ||:|..:...:.||.|..         |.: :|....
  Fly  1979 KERSLVAANLSRVTTSLRRQLHPQPQELDPERAERIKKLRRLHASTSGYRKAVNEFEEHLDQMAD 2043

Mouse  1550 AQFLALAVVYFISVLMVSKYRDILEPQRETARTGSQPGRN----IRQEINSPTSTVVVIPSIPHP 1610
            ...|..:.:..:|.:..:::|  |:.:|....:.:.|.|:    .|:.|              ||
  Fly  2044 CSNLNKSALRLLSPVEATRWR--LKFKRRHPTSANSPKRSPLKIARRRI--------------HP 2092

Mouse  1611 SLNHGLLAKLMPEQSFAHSFYKETPATFPDTVKEKETPTPGEDIQLESSVPH--TD--SGMG--- 1668
            .|:   |.|:.  |...||                 ||:.|     :||:|:  ||  ..:|
  Fly  2093 HLH---LGKIW--QPSGHS-----------------TPSSG-----QSSLPNRKTDFYDQLGIIR 2130

Mouse  1669 -EEQVASIL-DGAELEPAAGPDAMS------ELLSTLSSEVKKS-QESLTEHPSEMLKPAPSISS 1724
             ::::..:| |...|.|.:..|.::      |||..|:::...: ::::.:....:.|..||...
  Fly  2131 LQQRLLILLKDFLCLLPDSSVDVVTRHYVKLELLLVLANQRSCAVRQAIIQLVDVLTKRLPSGEL 2195

Mouse  1725 ISQTKGINVKEILKSLVAAPVEIA---ECGPEPIPYPDPALKREAHAILPMQFHSFDRSVVVPVK 1786
            .:.||.::...:...|.....::.   .|         .|.....|..| ....|.|..|.:..:
  Fly  2196 NAATKLMHPLHLANQLTIHGCDVGMFEAC---------LAWINGMHCSL-TDIQSCDAPVRIRQR 2250

Mouse  1787 KPPPGSLAVTTVGATAAGSGLPTGSTSSIFAAPGATP----KSMI--------NTTGAVDSGSSS 1839
            ...|..||:                      |.|..|    |:::        :.|..:::|...
  Fly  2251 FGLPSLLAI----------------------AEGTEPQWVFKALLRLYLQNPDDQTCLIEAGLLQ 2293

Mouse  1840 SSSSS-----SFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPL--------LRE 1891
            .|..:     |...|.::.:...|:.:|.:.             |||:..|..:        |..
  Fly  2294 CSVKALYKIYSLRVGQSNADESVVELLATIG-------------ERAMRSVGQINLVWDILNLLS 2345

Mouse  1892 IFVDFAPFLSRTLLGSHGQELLIEGL----------VCMKSSTSV--------VELVMLLCSQEW 1938
            .:.|..|.|......:...:|.:|.|          |.:.:.:|:        |||::..|:|.:
  Fly  2346 FYQDKQPQLIMRSFRTAQAQLQLEWLTKFFEPNSFRVAVTNDSSLSHSELRTRVELLIDRCTQFF 2410

Mouse  1939 QNSIQKNAG---------LAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKH---A 1991
            ...:.:..|         ||..:|     |:.:.:..: .|..|...:.|...|..|:..:   |
  Fly  2411 TVGVGQTTGPNYVASSQELALFQL-----LVSYGISSN-QRCNNFIAWGLQPSRPRDLRSYIVDA 2469

Mouse  1992 EFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQKILNI--------LTNKHGAWGAVS 2048
            .:.||..::......:.||...|:..:...|      :.:.|.|:        :.....:|..|
  Fly  2470 LWRSQQDEFQRAIICDAKMIKALLWLSLLED------MPEPIENLKPLCDALGIKENDSSWNLV- 2527

Mouse  2049 HSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKSAVEYGTE---EDVVKSKKAFRSQAIV 2110
                |:..|||...:::..:::            .||:..| |..|   :..|:|......:...
  Fly  2528 ----HELDRLDQNRNNMAAKQK------------TLLEKTV-YRFEPLVQQCVESSMVTTRKVAE 2575

Mouse  2111 NQNSETELML--------------------------------------------EG--------- 2122
            .||:|.:.::                                            ||
  Fly  2576 LQNAERKALMCHMKVYDDTYTYTKWLEIIRRMTHEGAPWHSAERAECSWELDDTEGPSRVHTRLR 2640

Mouse  2123 ----DDDAVSLLQE---------------KEIDNLAVSFLPKLFISRGPVVLSTPAQLIAPV-VV 2167
                |.|....:.|               :.:|.|..|:..:|.||....:|...|....|| ..
  Fly  2641 RCHLDIDRRFFMNEYRPGQGHREDLEPYVRPLDYLIASYDQQLNISLNSQILYNFAAKFLPVDGE 2705

Mouse  2168 AKGTLSITTTEIYFEVDEDDAAFK----KIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTAL 2228
            .:|.:.||..::||.     |.::    .::..:...||             ::.:||..|.||.
  Fly  2706 IEGEIIITDLKLYFL-----ATYRCRYFNVNCDIANITE-------------IWLKRYQHQETAF 2752

Mouse  2229 EVFMANRTSVMFNF--PDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQ 2291
            |:.:....|:.|:.  .|...:.:.|:               ..:| :|||.| .|...:||:|:
  Fly  2753 EILLDTNKSLFFSLQNADDWKIMREVF---------------CDKI-VATPDQ-SKVIAITQQWR 2800

Mouse  2292 RREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRA 2356
            ...::|:||||.||.|:|||||||.|||||||||.||.||.|||....|||.|.:||.....:..
  Fly  2801 EGLLTNWEYLMTLNQISGRTYNDLMQYPVFPWVLANYNSEVLDLREGHNFRRLGRPIAVQVEENE 2865

Mouse  2357 VFYAERYETWEEDQS-------PPFHYNTHYSTATSALSWLVRIEPFTTFFLNANDGKFDHPDRT 2414
            ..|...|...:...:       .|:||::|||.:.:.|.:|||:.|||::||...|..||.||||
  Fly  2866 KHYISNYTYIDSTNTTMGSLILKPYHYSSHYSNSGTVLHFLVRVPPFTSYFLRYQDNDFDLPDRT 2930

Mouse  2415 FSSIARSWRTSQRDT-SDVKELIPEFYYLPEMFVNSNGYHLGVREDEVVVNDVDLPPWAKKPED- 2477
            |.::..:|..:.||: :|||||||||:.|||||.|...:..|.|::...|.||.||||:::...
  Fly  2931 FHALNTTWLLASRDSPTDVKELIPEFFCLPEMFENFERFKFGCRQNGERVEDVSLPPWSQRDSRL 2995

Mouse  2478 FVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDS-ITDPVLREI 2541
            ||.|:|.|||||.|..|:|.||||||||||.|..||.|:||||..||  :|.||| |:||:.||
  Fly  2996 FVLIHRQALESELVRNQIHNWIDLIFGYKQSGESAVEAINVFHPATY--AVFLDSEISDPIERE- 3057

Mouse  2542 PEAYFIRDPHTFLLTKDFIKAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQ 2606
                                |::..::.:||.|.||...|||           ...||.:....:
  Fly  3058 --------------------AVKTMVKTYGQMPRQLFKSPHP-----------ASKPLDYSLVGK 3091

Mouse  2607 QDVIMV-------------LKFPS-----NSPVT-HVAA--NTLPHLTIPAVVTVTCSR---LFA 2647
            ..|..|             ||.||     ..|.| |:.:  ||.....:|...:|....   .:.
  Fly  3092 PIVSTVRGLRWGVYVGSPQLKAPSWANIHKIPGTEHLVSFCNTNVVYALPGRASVMQGAEPDTYN 3156

Mouse  2648 VNRWHNTVGLRGAPGYS--------LDQAHHLPIEM------DPLIANNSGVNKRQI-------- 2690
            |..|          ||.        |::....|..:      |.:.|....||..|:
  Fly  3157 VISW----------GYDDRIVRIQPLNKPQAKPKNLLHNGTFDDITACGCDVNSNQLWFGHKSGR 3211

Mouse  2691 ------TDLVDQSIQINAHCFVVTADNRYILICGF---WDKSFRVYST------------ETGKL 2734
                  |..:|...:       .:|.:|.....||   ::.:||..:.            |.|.|
  Fly  3212 ISVYKCTGGLDSQQR-------ASAKSRQSYARGFSLSYNSAFRKMTNKGIGGGGSERVDEAGNL 3269

Mouse  2735 TQIVFGHWDVVTCLARSESY-IGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVL 2798
                  |.........|.|. .|||.:    .||...|.|        :|.           .:|
  Fly  3270 ------HPTSSASSVNSSSISSGGDAF----QRDGADLNW--------LGP-----------TLL 3305

Mouse  2799 TGHDHEVVCVSVCAELGLVISGAKEG------------------PCLVH--TIT--------GDL 2835
            ..|..|:.|:::..|..:.::..::|                  |..:|  .||        ||:
  Fly  3306 VRHTDEITCITLSVEFKIAVTAGRDGIAVIWDLNDWSYVRTIARPAEIHQSPITHVAISPTLGDI 3370

Mouse  2836 LRALEGPENC------------LFPRLISVSSEGHCIIYYERGRFSNFSI--NGKLLAQM-EIN- 2884
            :.....|::|            ..|..::|:.|...:.......|.|.::  |||.:.:: .:|
  Fly  3371 VTVHTLPQSCNTSTDPKPTAVATRPNSLNVADECFEVTEENLDDFVNVNVNPNGKSILRLHSVNA 3435

Mouse  2885 ---------DSTRAILLS----SDGQNLV-TGGDNGVVEVWQA 2913
                     |...|:..|    ..|.|:: |..:.|.|..|.:
  Fly  3436 RYVQHLVHEDRILAVCYSYIKEGVGVNVIATAVEGGFVRFWSS 3478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nbea	XP_036019004.1	Laminin_G_3	245..392	CDD:463865	43/215 (20%)
		DUF4704	457..937	CDD:464870	121/663 (18%)
		DUF1088	1956..2122	CDD:461925	31/223 (14%)
		PH_BEACH	2159..2256	CDD:434260	21/103 (20%)
		Beach	2288..2585	CDD:460459	141/306 (46%)
		NBCH_WD40	2685..2957	CDD:466575	57/317 (18%)
		WD40 repeat	2746..2800	CDD:293791	11/54 (20%)
		WD40 repeat	2805..2840	CDD:293791	9/62 (15%)
		WD40 repeat	2845..2874	CDD:293791	6/42 (14%)
		WD40 repeat	2883..2921	CDD:293791	10/46 (22%)
		WD40 repeat	2929..2955	CDD:293791
mv	NP_647681.2	PH-like	2704..2785	CDD:473070	19/114 (17%)
		Beach	2796..3080	CDD:214982	142/317 (45%)
		WD40	<3302..>3518	CDD:441893	32/188 (17%)