DRSC/TRiP Functional Genomics Resources

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Protein Alignment GCGR and mthl6

DIOPT Version :10

Sequence 1:NP_000151.1 Gene:GCGR / 2642 HGNCID:4192 Length:477 Species:Homo sapiens
Sequence 2:NP_788473.1 Gene:mthl6 / 38839 FlyBaseID:FBgn0035789 Length:480 Species:Drosophila melanogaster


Alignment Length:392 Identity:79/392 - (20%)
Similarity:141/392 - (35%) Gaps:116/392 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    63 DKYSCW--------PDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDAS 119
            |:|..:        ||  .|.|  :|..||. .|.:::        .|:..|:.           
  Fly   153 DQYKLYENGSFMIKPD--VNWT--LSKQWYC-LHPRLE--------DPNSIWIL----------- 193

Human   120 QCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIH----ANL 180
                  |.:.:.|       |...:..|| ::|:...:|.:|:...:.||   ||.:.    ..:
  Fly   194 ------EHVYIPK-------SMPAVPQVG-TISMVGCILTIAVYLYIKKL---RNLLGKCFICYV 241

Human   181 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVE 245
            |..||               :|....|.||::  |.:.     |.:|.....:..:|::.||.|.
  Fly   242 FCKFV---------------QYLIWAGGDLNL--WNNI-----CSLAGYTNYFFALASHFWLSVM 284

Human   246 GLYLHNLLGLATLPERSF-FSLYLGIGWGAPML-----FVVPWAVVKCLFEN------------- 291
            ...:...|.|....|||: |.:|...|||.|.:     ::|.||     :|:             
  Fly   285 SHQIWKNLRLINRDERSYHFLIYNIYGWGTPAIMTAITYLVDWA-----WEDRPDKLNWIPGVGL 344

Human   292 VQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRA----------RQMHHTDYKFR 346
            .:||.:..:......|..|:.:..|.|...|:..|..:: |:::          :.:.:.|:...
  Fly   345 YRCWINTYDWSAMIYLYGPMLILSLFNVVTFILTVNHIM-KIKSSVKSSTQQQRKCIQNNDFLLY 408

Human   347 LAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSEL 411
            |..|  .::.:.|:.||:..||........:.....||.|    ..|::|.||:.......|..:
  Fly   409 LRLS--VMMGVTGISEVITYFVKRHKFWRQVLRVPNFFHL----GSGIVVFVLFILKRSTFQMIM 467

Human   412 RR 413
            .|
  Fly   468 ER 469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GCGRNP_000151.1 HRM 55..122 CDD:397086 12/66 (18%)
7tmB1_GCGR 136..410 CDD:320395 64/306 (21%)
TM helix 1 140..165 CDD:320395 6/24 (25%)
TM helix 2 174..196 CDD:320395 4/25 (16%)
TM helix 3 225..252 CDD:320395 5/26 (19%)
TM helix 4 264..284 CDD:320395 8/24 (33%)
TM helix 5 300..329 CDD:320395 6/28 (21%)
TM helix 6 345..370 CDD:320395 7/24 (29%)
Important for allosteric inhibitor binding. /evidence=ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 350..353 1/2 (50%)
TM helix 7 379..404 CDD:320395 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 431..477
mthl6NP_788473.1 Methuselah_N 25..195 CDD:429053 12/71 (17%)
7tmB3_Methuselah-like 211..471 CDD:410632 62/296 (21%)
TM helix 2 234..256 CDD:410632 5/36 (14%)
TM helix 3 264..291 CDD:410632 5/26 (19%)
TM helix 4 304..324 CDD:410632 6/19 (32%)
TM helix 5 353..382 CDD:410632 6/28 (21%)
TM helix 6 400..427 CDD:410632 6/28 (21%)
TM helix 7 435..460 CDD:410632 7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

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