DRSC/TRiP Functional Genomics Resources

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Protein Alignment GCGR and Dh31-R

DIOPT Version :10

Sequence 1:NP_000151.1 Gene:GCGR / 2642 HGNCID:4192 Length:477 Species:Homo sapiens
Sequence 2:NP_001260951.1 Gene:Dh31-R / 36475 FlyBaseID:FBgn0052843 Length:604 Species:Drosophila melanogaster


Alignment Length:463 Identity:128/463 - (27%)
Similarity:196/463 - (42%) Gaps:102/463 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    58 CNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGP-RGQPWRDASQC 121
            |..|||.:.|||||...|:|...||.::......  |:..|.||.||:|.:.| ..:.|.:.:.|
  Fly    68 CAGTFDGWLCWPDTAVGTSAYELCPDFITGFDPA--RYAHKECGLDGEWFKHPLTNKTWSNYTTC 130

Human   122 QMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVL 186
                    |..|......:..::..|||..||.|:||:|||||....|.|.|..:|.||||||..
  Fly   131 --------VNLEDLNWRHTVNLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAA 187

Human   187 KASSVLVIDGLLRTRYSQKIGDDLSVSTW---------LSDGAVAGCRVAAVFMQYGIVANYCWL 242
            ..|..||                     |         |...:...|....:.:.|.:::||.|:
  Fly   188 NNSLWLV---------------------WYLLVMPNSELLHQSPMRCVALHITLHYFLLSNYSWM 231

Human   243 LVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCL----FENVQCWTSNDNMGF 303
            |.||.|||.:|..|.:.|:......:..|||:|.:.:..:::.:.|    .:|..||.:..|  :
  Fly   232 LCEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMNQTN--Y 294

Human   304 WWILRFPVFLAILINFFIFVRIVQLLVAKLRA-----------RQMHHTDYKFRLAKSTLTLIPL 357
            ..||..||.:::.:|......||::::.||.|           |.:      .:..::||.|:||
  Fly   295 QNILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRTV------LQAFRATLLLVPL 353

Human   358 LGVHEVVFAF-VTDEHA-QGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRW-- 418
            ||:..::..| ...:|. :.|..    ....|.:|||||.||:|:||.|.||.::::|:|...  
  Fly   354 LGLQYILTPFRPAPKHPWENTYE----IISAFTASFQGLCVAILFCFCNGEVIAQMKRKWRMMCF 414

Human   419 -----------------RLGKVLWEERN------TSNHRASSSPGHGPP-------SKELQFGRG 453
                             |.|..|..|..      ::..|||:.|.|..|       |.:.|..|.
  Fly   415 SNRPRTNSYTATQVSFVRCGPPLPGEEKVXLKDMSAKRRASAGPQHHQPHHQSHQLSTDQQRARS 479

Human   454 GGSQDSSA 461
            .....||:
  Fly   480 QSLASSSS 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GCGRNP_000151.1 HRM 55..122 CDD:397086 22/64 (34%)
7tmB1_GCGR 136..410 CDD:320395 86/299 (29%)
TM helix 1 140..165 CDD:320395 12/24 (50%)
TM helix 2 174..196 CDD:320395 10/21 (48%)
TM helix 3 225..252 CDD:320395 10/26 (38%)
TM helix 4 264..284 CDD:320395 4/19 (21%)
TM helix 5 300..329 CDD:320395 8/28 (29%)
TM helix 6 345..370 CDD:320395 8/25 (32%)
Important for allosteric inhibitor binding. /evidence=ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 350..353 1/2 (50%)
TM helix 7 379..404 CDD:320395 11/24 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 431..477 11/38 (29%)
Dh31-RNP_001260951.1 HRM 65..132 CDD:397086 23/73 (32%)
7tmB1_NPR_B4_insect-like 139..411 CDD:320388 88/304 (29%)
TM helix 1 141..166 CDD:320388 12/24 (50%)
TM helix 2 175..197 CDD:320388 11/42 (26%)
TM helix 3 214..241 CDD:320388 10/26 (38%)
TM helix 4 253..273 CDD:320388 4/19 (21%)
TM helix 5 291..320 CDD:320388 8/30 (27%)
TM helix 6 339..366 CDD:320388 8/32 (25%)
TM helix 7 373..398 CDD:320388 12/28 (43%)

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