Protein Alignment GCGR and Dh44-R2

DIOPT Version :10

• Sequence 1: NP_000151.1
• Gene: GCGR / 2642
• HGNCID: 4192
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_610789.3
• Gene: Dh44-R2 / 36368
• FlyBaseID: FBgn0033744
• Length: 476
• Species: Drosophila melanogaster
• Alignment Length: 397
• Identity: 126/397 - (31%)
• Similarity: 183/397 - (46%)
• Gaps: 53/397 - (13%)

Human    56 LVCNRTFDKYSCWPDTPANTTANISC-PWYLPWHHKVQH---RFVFKRCGPDGQWVRGPRGQPWR 116
            |.|..:||...|||.|.|.:.|.:.| ..:...|:....   ||    |.|:|.|      ..:.
  Fly    82 LQCPSSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATRF----CFPNGTW------DHYS 136

Human   117 DASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLF 181
            |..:|..:...|.|..:.:.......::|..||.||...|::||.|......|.|.||.||||||
  Fly   137 DYDRCHQNSGSIPVVPDFSPNVELPAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLF 201

Human   182 ASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEG 246
            .:::  .|::|.|..|.           |.|.|  ::.:.|||....:..||..:.|:.|:.|||
  Fly   202 LTYI--TSALLWILTLF-----------LQVIT--TESSQAGCITLVIMFQYFYLTNFFWMFVEG 251

Human   247 LYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCL---FEN-------VQC-WTSNDN 300
            |||:.|:......:...|.:|..||||.|.:.::.|::.|..   .||       :.| |....:
  Fly   252 LYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESH 316

Human   301 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVF 365
            :.  ||.:.|..||:|:|....:||:.:|:.|||:.....|...::.:|:.|.||||.|   :.:
  Fly   317 ID--WIFKVPASLALLVNLVFLIRIMWVLITKLRSAHTLETRQYYKASKALLVLIPLFG---ITY 376

Human   366 AFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNT 430
            ..|.....||..|:.......||.|.||..||:.|||||.||:..||..:.|||      |.||.
  Fly   377 LLVLTGPEQGISRNLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWR------ESRNI 435

Human   431 SNHRASS 437
              ||.||
  Fly   436 --HRNSS 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCGR	NP_000151.1	HRM	55..122	CDD:397086	19/69 (28%)
		7tmB1_GCGR	136..410	CDD:320395	92/284 (32%)
		TM helix 1	140..165	CDD:320395	9/24 (38%)
		TM helix 2	174..196	CDD:320395	10/21 (48%)
		TM helix 3	225..252	CDD:320395	10/26 (38%)
		TM helix 4	264..284	CDD:320395	8/19 (42%)
		TM helix 5	300..329	CDD:320395	9/28 (32%)
		TM helix 6	345..370	CDD:320395	8/24 (33%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451	350..353		0/2 (0%)
		TM helix 7	379..404	CDD:320395	10/24 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..477		4/7 (57%)
Dh44-R2	NP_610789.3	HRM	82..144	CDD:397086	20/71 (28%)
		7tmB1_DH_R	158..428	CDD:320391	94/289 (33%)
		TM helix 1	160..185	CDD:320391	9/24 (38%)
		TM helix 2	194..216	CDD:320391	10/23 (43%)
		TM helix 3	230..257	CDD:320391	10/26 (38%)
		TM helix 4	269..289	CDD:320391	8/19 (42%)
		TM helix 5	314..343	CDD:320391	9/30 (30%)
		TM helix 6	357..384	CDD:320391	8/29 (28%)
		TM helix 7	390..415	CDD:320391	10/24 (42%)