Protein Alignment GCGR and Pdfr

DIOPT Version :10

• Sequence 1: NP_000151.1
• Gene: GCGR / 2642
• HGNCID: 4192
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Alignment Length: 464
• Identity: 128/464 - (27%)
• Similarity: 201/464 - (43%)
• Gaps: 84/464 - (18%)

Human    52 PPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQP-- 114
            |.|.|.||.|:|...|||.|||...|.::||.  .:|.....:|..::|..||:|...|....
  Fly   210 PQTGLYCNWTWDTLLCWPPTPAGVLARMNCPG--GFHGVDTRKFAIRKCELDGRWGSRPNATEVN 272

Human   115 ---WRDASQC----------QMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGL 166
               |.|...|          ||..::.:...::|:...:.::   ||..|||.||:::|.|....
  Fly   273 PPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEI---VGLCLSLFALIVSLLIFCTF 334

Human   167 SKLHCTRNAIHANLFASFVLKA--SSVLVIDGLLRTRYSQKIGDDLSV---STWLSDGAVAGCRV 226
            ..|...|..||.|||.:.||:.  ...|.:|...|..........|||   :.:|       |..
  Fly   335 RSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYL-------CEA 392

Human   227 AAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFEN 291
            :.|.::|...|.:.|:.:|||||||::.:|..........:..:||..|:|....||....::.:
  Fly   393 SYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMD 457

Human   292 V---QCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLT 353
            .   :|..:.:...::|||..|....||:||...|.|:::||.|||..|....:...:..::.:.
  Fly   458 TSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIV 522

Human   354 LIPLLGVHEVVFAFVTDEHAQGTLRSAKLFF-----DLFLSSFQGLLVAVLYCFLNKEVQ----- 408
            |:||||:..::       |....|::|..|.     ..||:||||..:|::|||||.||:
  Fly   523 LLPLLGITNLL-------HQLAPLKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLK 580

Human   409 ---SELRRRWHRWRLGKVLWEERNTSNHRAS----------------SSPGH--GPPSKELQFGR 452
               ::|..|.|      ..|..:..|.:..:                |:.|.  .||:|.|
  Fly   581 SLATQLSVRGH------PEWAPKRASMYSGAYNTAPDTDAVQPAGDPSATGKRISPPNKRL---- 635

Human   453 GGGSQDSSA 461
             .|.:.|||
  Fly   636 -NGRKPSSA 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCGR	NP_000151.1	HRM	55..122	CDD:397086	24/81 (30%)
		7tmB1_GCGR	136..410	CDD:320395	84/294 (29%)
		TM helix 1	140..165	CDD:320395	9/24 (38%)
		TM helix 2	174..196	CDD:320395	8/23 (35%)
		TM helix 3	225..252	CDD:320395	10/26 (38%)
		TM helix 4	264..284	CDD:320395	5/19 (26%)
		TM helix 5	300..329	CDD:320395	10/28 (36%)
		TM helix 6	345..370	CDD:320395	5/24 (21%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451	350..353		0/2 (0%)
		TM helix 7	379..404	CDD:320395	12/29 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..477		11/49 (22%)
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	21/60 (35%)
		7tmB1_PDFR	306..584	CDD:320389	85/294 (29%)
		TM helix 1	308..333	CDD:320389	9/27 (33%)
		TM helix 2	342..364	CDD:320389	8/21 (38%)
		TM helix 3	391..418	CDD:320389	10/26 (38%)
		TM helix 4	430..450	CDD:320389	5/19 (26%)
		TM helix 5	469..498	CDD:320389	10/28 (36%)
		TM helix 6	512..539	CDD:320389	6/33 (18%)
		TM helix 7	546..571	CDD:320389	10/24 (42%)