DRSC/TRiP Functional Genomics Resources

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Protein Alignment GCGR and mthl12

DIOPT Version :10

Sequence 1:NP_000151.1 Gene:GCGR / 2642 HGNCID:4192 Length:477 Species:Homo sapiens
Sequence 2:NP_731791.2 Gene:mthl12 / 261599 FlyBaseID:FBgn0045442 Length:488 Species:Drosophila melanogaster


Alignment Length:424 Identity:73/424 - (17%)
Similarity:136/424 - (32%) Gaps:132/424 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    14 LLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTAN 78
            ||:|..|.| |..:::....:::.:..|    ...||....|::.|   |:|..:|:..::....
  Fly   145 LLILREQFQ-PCDEIVSLKRDEYTILKD----GSILLHTSAEILSN---DQYCLYPEIYSDFPET 201

Human    79 ISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQV 143
            |              |.:.:||                              .:.|....:...|
  Fly   202 I--------------RIINRRC------------------------------YRNVMPGIAQLSV 222

Human   144 MYTVGYSLSLGALLLALAILGGLSKLHCTRN----AIHANLFASFVLKASSVLVIDGLLRTRYSQ 204
            :..||:       :|.||:...:.||   ||    .:..:||:.|:  ...:..:|..   |..|
  Fly   223 ISVVGF-------ILTLAVYLSVEKL---RNLLGKCLICSLFSMFM--EYFIWTMDYF---RLLQ 272

Human   205 KIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSF-FSLYL 268
            .|                 |..|.....:..:::|.|..|...:|..|.......|..: |.:|.
  Fly   273 SI-----------------CSAAGYMKYFFSMSSYLWFSVVSFHLWELFTSLNRHEPQYRFLIYN 320

Human   269 GIGWGAPMLFVVPWAVVKCLFENVQCWTSND--------------------NMGFWWILRFPVFL 313
            ...|   ....:|..|:   |...|.| .||                    |...|:....|:.:
  Fly   321 TFVW---CTAAIPTVVI---FSMNQMW-ENDPGKSEWLPLVGYFGCSVKDWNSSSWFYSHIPIVI 378

Human   314 AILINFFIFVRIVQLLVAKLR----------ARQMHHTDYKFRLAKSTLTLIPLLGVH---EVVF 365
            ....|..:|| :..:.:.|::          .|.....::..:.....:.|..::|..   :.:.
  Fly   379 LNSFNVIMFV-LTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLLDQLT 442

Human   366 AFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVL 399
            ....|.|.  .|.:..|...::|::..|:|:.||
  Fly   443 RLAEDSHL--LLDTIVLNLTVYLNAAFGILIFVL 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GCGRNP_000151.1 HRM 55..122 CDD:397086 9/66 (14%)
7tmB1_GCGR 136..410 CDD:320395 54/302 (18%)
TM helix 1 140..165 CDD:320395 6/24 (25%)
TM helix 2 174..196 CDD:320395 4/25 (16%)
TM helix 3 225..252 CDD:320395 5/26 (19%)
TM helix 4 264..284 CDD:320395 4/19 (21%)
TM helix 5 300..329 CDD:320395 6/28 (21%)
TM helix 6 345..370 CDD:320395 2/27 (7%)
Important for allosteric inhibitor binding. /evidence=ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 350..353 0/2 (0%)
TM helix 7 379..404 CDD:320395 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 431..477
mthl12NP_731791.2 Methuselah_N 27..209 CDD:429053 16/85 (19%)
7tmB3_Methuselah-like 220..488 CDD:410632 54/297 (18%)
TM helix 2 246..268 CDD:410632 4/23 (17%)
TM helix 3 276..303 CDD:410632 5/26 (19%)
TM helix 4 316..336 CDD:410632 5/25 (20%)
TM helix 5 364..394 CDD:410632 6/30 (20%)
TM helix 6 410..444 CDD:410632 3/33 (9%)
TM helix 7 449..479 CDD:410632 8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

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