DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mapk14 and p38b

DIOPT Version :9

Sequence 1:	NP_001161980.1	Gene:	Mapk14 / 26416	MGIID:	1346865	Length:	360	Species:	Mus musculus
Sequence 2:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	245/353 - (69%)
Similarity:	287/353 - (81%)	Gaps:	3/353 - (0%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHA 65
            ||::...||:.::|:|.||:||.||||.|||.||||.||.|....|..:||:|||:|||||.:||
  Fly     1 MSRKMAKFYKLDINRTEWEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHA 65

Mouse    66 KRTYRELRLLKHMKHENVIGLLDVF---TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
            |||||||||||||.|||||||||||   .||.||::|..||:|||||.||||||::.|||:||||
  Fly    66 KRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQKLSDDHV 130

Mouse   128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPE 192
            |||:|||||||||||||.:|||||||||:||||||||:||||||||..:.|||||||||||||||
  Fly   131 QFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEMTGYVATRWYRAPE 195

Mouse   193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARN 257
            |||||||||||.|||||||||||||||||||||||||:||..||.:.|||....::|:.|..|||
  Fly   196 IMLNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARN 260

Mouse   258 YIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP 322
            ||:||..||:.||.::|.||||||:|||||||.||:||||||.|||||.|..:||||.||..|..
  Fly   261 YIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPTDEQTAAL 325

Mouse   323 YDQSFESRDLLIDEWKSLTYDEVISFVP 350
            ||||||..:|.:::|:.:.:.||.:|.|
  Fly   326 YDQSFEENELPVEKWREMVFSEVTAFKP 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mapk14	NP_001161980.1	STKc_p38alpha	6..350	CDD:143382	242/346 (70%)
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	242/344 (70%)
p38b	NP_477361.1	S_TKc	24..311	CDD:214567	215/286 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836771
Domainoid	1	1.000	453	1.000	Domainoid score	I501
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31777
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1247
Isobase	1	0.950	-	0	Normalized mean entropy	S378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	1	1.000	-	-		mtm8731
orthoMCL	1	0.900	-	-		OOG6_102675
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R566
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740