DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Map3k12 and slpr

DIOPT Version :9

Sequence 1:	NP_001157115.1	Gene:	Map3k12 / 26404	MGIID:	1346881	Length:	888	Species:	Mus musculus
Sequence 2:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	1022	Identity:	249/1022 - (24%)
Similarity:	376/1022 - (36%)	Gaps:	356/1022 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse   152 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLR-----------KLKHPN 205
            |:.:.|:...:.:|||....|..|.:.|||||:|......|.|::.:|           .|||.|
  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHEN 187

Mouse   206 IITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLH---KIIH 267
            |...:|||.... .|::||:...|.|..:| ||: :.|.:||:|::.||.||||||..   .|||
  Fly   188 IAALRGVCLNTK-LCLVMEYARGGSLNRIL-AGK-IPPDVLVNWAIQIARGMNYLHNEAPMSIIH 249

Mouse   268 RDLKSPNMLITYDDV---------VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 323
            |||||.|:|| |:.:         :||:|||.::|:.: :.:||.|||.|||.||||.....|:.
  Fly   250 RDLKSSNVLI-YEAIEGNHLQQKTLKITDFGLAREMYN-TQRMSAAGTYAWMPPEVISVSTYSKF 312

Mouse   324 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRP 388
            .|:||:||:||||:|||.|||..|..::.:||..|:|.||:|.:||:.:..|::.||.:.|..||
  Fly   313 SDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRP 377

Mouse   389 SFRQILLHLD-IASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREEL 452
            .|::||..|: ||.:....||||::...|..||:|:......::.:......:||||  |.:||.
  Fly   378 GFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEEL--RNKEEQ 440

Mouse   453 RHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHPSRGLLHGN 517
            .    :|...|:: |:||           .|:::|:.|..||:.|..|...:|:..||:
  Fly   441 L----LRVQNEQR-EKAN-----------LLKIREQNLRERERVLIERELVMLQPVPSK------ 483

Mouse   518 TMEKLIK-KRNVPQKLS-PHSKRPDIL-------------------------------------- 542
              .|..| |:|.|.::| |...|..|.
  Fly   484 --RKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQ 546

Mouse   543 KTESLLPKLDAALSGVGLPGCP----------KGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRA 597
            :..||||   :.||| |.|..|          |..|:..:.::.:.:.:.||....    |||..
  Fly   547 RERSLLP---SQLSG-GQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPP----PGLGI 603

Mouse   598 ALPPHEPGGLGSPGGLGVGPSAWDACPPALR---------------------------------- 628
            .      ||.|..||....|..:...|..|.
  Fly   604 L------GGSGGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNS 662

Mouse   629 -GLHHDLLLRKMS-------------SSSPDLLSAALGARGRGATGGARDPGSP----------- 668
             ..:::..|..:|             :|.|:.:...  ..||..:..:....||
  Fly   663 ISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVL--QNGRNNSNSSTTSQSPAKIYHRARSQE 725

Mouse   669 ----------PPP---------QGDTPPS------------EGSAPGSTSPDSPGGAKGEPP--- 699
                      |||         :.||..|            ..:|.|:......||:.|..|
  Fly   726 YGLDHPLAYQPPPLYLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVG 790

Mouse   700 ------------PPVGPGEGVGLLG---------------------------------------- 712
                        ||........|..
  Fly   791 RKKHSLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDL 855

Mouse   713 ---------TGRE----GTAGRGG----NRAGSQHLTPAALLYRAAVTRSQKRGISSEEE----- 755
                     |.|:    ..|..||    |.:|||.  |....:    ||.::.|.:.:|:
  Fly   856 TMYNSSTPLTARDCDDAEEAFEGGRFQRNFSGSQF--PRHCFF----TRQEEEGEAEDEDAVAAE 914

Mouse   756 ----EGEVDSEVELPPSQRWPQGPNMRQSLSTFSS---ENP-----------SDVEEGTAS---- 798
                :.:.|.|.::|.||........|:|..||.|   |.|           ||:...:||
  Fly   915 VDTADADADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASISFA 979

Mouse   799 -----EPS-------PSGTPEVGST--------------NT----DERP---------DERSDDM 824
                 .||       .|.:|.:.||              ||    |.:|         .|:....
  Fly   980 TYRSASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRAQEQRQQT 1044

Mouse   825 CSQGSEIPLDLPTSEVVPEREASSLPMQHQDGQGPNPEDSDCDSTEL 871
            .:|..:.|..:..|:.| |........:|.|...|..:.....|:::
  Fly  1045 KNQKKQRPKHITKSKSV-EAPVEGQHHEHDDHNDPQHQHHSAGSSKI 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Map3k12	NP_001157115.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..104
		STKc_MAP3K12_13	164..400	CDD:270961	108/259 (42%)
		Leucine-zipper 1	423..444		2/20 (10%)
		Leucine-zipper 2	476..497		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..612		14/64 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..888		69/398 (17%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	107/261 (41%)
		STKc_MLK	134..389	CDD:270963	108/259 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010