Protein Alignment Map2k4 and lic

DIOPT Version :10

• Sequence 1: NP_001303296.1
• Gene: Map2k4 / 26398
• MGIID: 1346869
• Length: 408
• Species: Mus musculus
• Sequence 2: NP_477162.1
• Gene: lic / 32257
• FlyBaseID: FBgn0261524
• Length: 334
• Species: Drosophila melanogaster
• Alignment Length: 337
• Identity: 174/337 - (51%)
• Similarity: 241/337 - (71%)
• Gaps: 8/337 - (2%)

Mouse    67 RFTLNPNTTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHK 131
            |..|.|.|. .:.|....:...:::|...::|. ::.:|..|:.|:.:.::||||||.|:||.||
  Fly     4 RHRLTPFTI-AKEPEAAIVPPRNLDSRATIQIG-DRTFDIDADSLEKICDLGRGAYGIVDKMRHK 66

Mouse   132 PSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDK 196
            .:..::|||||..||:.:||.:|:||||:.||||||||.|.||||::||||.|||||:||||.||
  Fly    67 QTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDK 131

Mouse   197 FYKYVYSVLDDV-IPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGIS 260
            ||..|:  |.|: :.|.:||||.::.|.||::|...||:||||:||||||::|:|.:|:||||||
  Fly   132 FYPKVF--LHDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGIS 194

Mouse   261 GQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQ 325
            |.||||||||.||||:||||||||||..:...||:|||||||||.:.|:||||:||..|.:.|:|
  Fly   195 GYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQ 259

Mouse   326 LTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYV 390
            |.|||:..||:|   .|..|||.|.:|:.:||.|:...||.|::||||.||:.:.:|..:::.:|
  Fly   260 LRQVVEDSPPRL---PEGTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISEFV 321

Mouse   391 CKILDQMPATPS 402
            .:|||...|.|:
  Fly   322 ARILDLPDAQPA 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Map2k4	NP_001303296.1	PKc_MKK4	104..394	CDD:270790	162/290 (56%)
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	161/286 (56%)