Protein Alignment GBX2 and E5

DIOPT Version :10

• Sequence 1: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 426
• Identity: 94/426 - (22%)
• Similarity: 125/426 - (29%)
• Gaps: 200/426 - (46%)

Human     1 MSAAFPPSLMMMQRPLGSSTAFSIDSLIG---------------SPPQPS--------------- 35
            :||:...|.....:|   ..||||||::|               |||..|
  Fly    34 VSASSTVSASASSKP---KLAFSIDSIVGESSTRSAPLRVSVISSPPPRSESPASPTNTNNSGRR 95

Human    36 -PGHFVY----------------------------------------------TGYPMFMPYRPV 53
             |..::|                                              ||.|..: .||:
  Fly    96 TPRGYIYCRRRDSLDRSRSPQRSPVSRSPSPPNAGGNPAAAGNTAKSGDPSSGTGNPPTL-IRPL 159

Human    54 VLPPP--------------------PPPPPALP----QAALQPALPPAHPH--------HQIPSL 86
            .||.|                    ||.||:.|    .|..|.|...||.|        .|:|.:
  Fly   160 PLPAPNLALIGNRTSPNAMAVRMAGPPHPPSQPPPFLAAQFQMAAALAHHHQQQQQQQQQQLPPV 224

Human    87 PTGFCSSLAQGMALTSTLMATLPGGFSASPQHQEAAAARKFAPQPLPGGGN-FDKAEALQADAED 150
            |||........:......:...|||  ..|.|            |.|.|.: |..|..|..|:..
  Fly   225 PTGPPHGPHPHLPPGQIPLGIFPGG--PHPGH------------PPPHGHHPFGSAPHLIRDSYP 275

Human   151 -GKGFLAKEGSLLAFSAAETVQASLVGAVRGQGKDESKVEDDPKGKEESFSLESDVDYSSDDNLT 214
             ....|::.|.:.                             |:
  Fly   276 LYPWLLSRHGRIF-----------------------------PR--------------------- 290

Human   215 GQAAHKEEDPGHALEETPPSSGAAGSTTSTGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQ 279
                    .||:.|.:            ...|.:|.||||:..|||:||..|....|:...||.|
  Fly   291 --------FPGNFLFQ------------PFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQ 335

Human   280 IAHALKLSEVQVKIWFQNRRAKWKRV-KAGNANSKT 314
            :|..|.|:|.|||:||||||.|.||: :.|...|.|
  Fly   336 LAQGLSLTETQVKVWFQNRRTKHKRMQQEGGDGSDT 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81		11/33 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		6/71 (8%)
		Homeodomain	248..304	CDD:459649	29/55 (53%)
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	29/55 (53%)