Protein Alignment GBX2 and Scr

DIOPT Version :10

• Sequence 1: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 391
• Identity: 104/391 - (26%)
• Similarity: 144/391 - (36%)
• Gaps: 124/391 - (31%)

Human    29 GSPPQPSPGHFVYTGYPMFMPYRPVVLPPPPPP-------------PPALPQAALQP---ALPPA 77
            ||....:||...|  :|....|.|.:.|..|..             |..:....|||   .|...
  Fly    63 GSAGAATPGANDY--FPAAAAYTPNLYPNTPQAHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQQ 125

Human    78 HPHHQIPSLPTGFCSSLAQGMALTSTLMATLPGGFSASPQH-------QEAAAARKFAPQPL-PG 134
            ....|             |..|..:..:|.......|..||       |:|..:.|:|..|: ||
  Fly   126 QQQQQ-------------QQHAHAAAAVAAQQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPG 177

Human   135 G-----------------GNFDKAEALQADAED-----------------------GKGFLAKEG 159
            |                 .|.:.:::| |..:|                       .||.|.  |
  Fly   178 GSGGGGVSGSNNNNNSANSNNNNSQSL-ASPQDLSTRDISPKLSPSSVVESVARSLNKGVLG--G 239

Human   160 SLLAFSAAETVQASLVGAVRGQGKDESKVEDDPKGKEESFSLESDVDYSSDDNLTGQAAHKEEDP 224
            ||.|.:||..:..:..|:....|.....|.....|..:|.| |||         :|..|...::.
  Fly   240 SLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDS-ESD---------SGNEAGSSQNS 294

Human   225 GHALEETP---PSSGAAGSTTST----GKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAH 282
            |:..:..|   |........|||    |:.:|:||::|..|.||||||||..:||:...|.:|||
  Fly   295 GNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAH 359

Human   283 ALKLSEVQVKIWFQNRRAKWKRV-KAGNANSKTGEPSRNPKIVVP------------IPVHVSRF 334
            ||.|:|.|:||||||||.|||:. |..:.|            :||            ..:|.|:|
  Fly   360 ALCLTERQIKIWFQNRRMKWKKEHKMASMN------------IVPYHMGPYGHPYHQFDIHPSQF 412

Human   335 A 335
            |
  Fly   413 A 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81		6/37 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		12/52 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		18/78 (23%)
		Homeodomain	248..304	CDD:459649	34/55 (62%)
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	34/55 (62%)