Protein Alignment GBX2 and bsh

DIOPT Version :10

• Sequence 1: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_477350.2
• Gene: bsh / 35266
• FlyBaseID: FBgn0000529
• Length: 429
• Species: Drosophila melanogaster
• Alignment Length: 284
• Identity: 67/284 - (23%)
• Similarity: 85/284 - (29%)
• Gaps: 117/284 - (41%)

Human    49 PYRPVVLPPPPPPPP-----ALPQAALQPALPPAHPHHQIPSLPTGFCSSLAQGMALTSTLMATL 108
            |..|...|.||||||     ......|.|..|  :..|....:..|:.|
  Fly   177 PPVPTTQPQPPPPPPLNGGSGASNGVLYPNAP--YTDHGFLQMTLGYLS---------------- 223

Human   109 PGGFSASPQHQEAAAARKFAPQPLPGGGNFDKAEALQADAEDGKGFLAKEGSLLAFSAAETVQAS 173
                                    |..|.:...:..         ||:              |||
  Fly   224 ------------------------PSSGTYKSVDPY---------FLS--------------QAS 241

Human   174 LVGAVRGQGKDESKVEDDPKGKEESFSLESDVDYSSDDNLTGQAAHKEEDPGHALEETPPSSGAA 238
            |.|.....|.                                        || .:.|.....|..
  Fly   242 LFGGAPFFGA----------------------------------------PG-CVPELALGLGMG 265

Human   239 GSTTSTGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWK 303
            .:.....:.|:.||.|:..||..|||.|..::|||..||.::|.||.|||.|||.||||||.|.|
  Fly   266 VNALRHCRRRKARTVFSDPQLSGLEKRFEGQRYLSTPERVELATALGLSETQVKTWFQNRRMKHK 330

Human   304 RV--KAGNANS----KTGEPSRNP 321
            :.  :..|||.    ...||.:.|
  Fly   331 KQLRRRDNANEPVDFSRSEPGKQP 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81		8/26 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		2/27 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		6/71 (8%)
		Homeodomain	248..304	CDD:459649	31/55 (56%)
bsh	NP_477350.2	Homeodomain	275..331	CDD:459649	31/55 (56%)