Protein Alignment GBX2 and B-H1

DIOPT Version :10

• Sequence 1: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Alignment Length: 273
• Identity: 87/273 - (31%)
• Similarity: 114/273 - (41%)
• Gaps: 61/273 - (22%)

Human    52 PVVLPPPPPPPPALPQAALQPALPPA--HPHHQIPSLPTGFCSSLAQGMALTSTLMATLPGGFSA 114
            |..|..|.|.||..|...     |.|  |||.::...|     ..|.|..|.....|      :|
  Fly   144 PSALHHPQPHPPTHPHTH-----PHALMHPHGKLGHFP-----PTAGGNGLNVAQYA------AA 192

Human   115 SPQHQEAAAARKFAPQPLPGGGNFDKAEALQADAEDGKGFLAKEGSLLAFSAAETVQASLVGAVR 179
            ..||..||||...|       .|...|.|..|.|....|.           ||..|...:.|.|.
  Fly   193 MQQHYAAAAAAAAA-------RNNAAAAAAAAAAAAAAGV-----------AAPPVDGGVDGGVG 239

Human   180 GQGKDESKVEDDPKGKEESFSLESDVDYSSDDNLTGQAAHKEEDPGHALEETPPSSGAAGSTTS- 243
            ........::|.....||:...:|.   :.||:.......|::| |::::        :|||:.
  Fly   240 LAPPAGGDLDDSSDYHEENEDCDSG---NMDDHSVCSNGGKDDD-GNSVK--------SGSTSDM 292

Human   244 ---TGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKR- 304
               :.|.|:.|||||..||..|||.|..:||||:.||.::||.|.||:.|||.|:||||.||||
  Fly   293 SGLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKRQ 357

Human   305 --------VKAGN 309
                    .:|||
  Fly   358 TAVGLELLAEAGN 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81		8/23 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		9/27 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		14/75 (19%)
		Homeodomain	248..304	CDD:459649	33/55 (60%)
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	33/55 (60%)