Protein Alignment GBX2 and B-H2

DIOPT Version :10

• Sequence 1: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_523386.1
• Gene: B-H2 / 32723
• FlyBaseID: FBgn0004854
• Length: 645
• Species: Drosophila melanogaster
• Alignment Length: 303
• Identity: 82/303 - (27%)
• Similarity: 125/303 - (41%)
• Gaps: 39/303 - (12%)

Human    30 SPPQPSPGHFVYTGYPMFMPYRPVVLPPPPPPPPALPQAALQPALPPAHPH--------HQIPSL 86
            |||..:|    |..:||    .|.:|...||...|:.|...|......|||        .::.:|
  Fly   165 SPPGNNP----YAHHPM----PPHLLAHFPPAHYAVLQQQQQQQQQQQHPHPHHLQLERERLEAL 221

Human    87 PT---GFCSSLAQGMALTSTLMATLPGGFSASPQHQEAAAARKFAPQPLPGGGNFDKAEALQADA 148
            ..   |.....||.::..|.|...........|.|.|.:.:.....|....|||.:......:.|
  Fly   222 HRHGHGLTGDPAQHLSHLSHLSHQQHHPHLHHPMHDERSRSPLMLQQLGGNGGNNNNNNNNSSSA 286

Human   149 EDGKGFLAKEGSLLAFSAAETVQASLVGAVRGQGKDESKVEDDPKGKEESFSLESDVDYSSDDNL 213
            .:..    ...:..|.:.:..:..:...:....|.....:.....|...|....|.:|.|..|:.
  Fly   287 SNNN----NNNNNSASANSNIISGNSSSSNNNNGSGNGNMLLGGPGSSISGDQASTIDDSDSDDC 347

Human   214 TGQAAHKEEDPGHALEETPPSSGAAGSTTS---TGKNRRRRTAFTSEQLLELEKEFHCKKYLSLT 275
            .|    |::|...:::....::|.:.|..|   :.|.|:.|||||..||..|||.|..:||||:.
  Fly   348 GG----KDDDGDDSMKNGSSANGDSSSHLSLSLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQ 408

Human   276 ERSQIAHALKLSEVQVKIWFQNRRAKWKR---------VKAGN 309
            :|.::|:.|:||:.|||.|:||||.||||         .:|||
  Fly   409 DRMELANKLELSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGN 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81		8/29 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		15/74 (20%)
		Homeodomain	248..304	CDD:459649	31/55 (56%)
B-H2	NP_523386.1	Homeodomain	381..437	CDD:459649	31/55 (56%)