DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axl and Eph

DIOPT Version :9

Sequence 1:	NP_033491.2	Gene:	Axl / 26362	MGIID:	1347244	Length:	888	Species:	Mus musculus
Sequence 2:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	976	Identity:	235/976 - (24%)
Similarity:	376/976 - (38%)	Gaps:	276/976 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    29 SPFVGNPGNITGARGLTGTLRCELQVQGEPPEVVWLRD-----GQILELAD---------NTQTQ 79
            |||:.        ||....|..|:|..        :||     |..|...:         :..|:
  Fly   145 SPFID--------RGSANRLYIEIQFT--------IRDCSLFPGNALSCKETFSLLFYEFDAATR 193

Mouse    80 VPLGEDWQ-DEWKVVSQL-----------------RISALQLSDAGEY-------QCMVHLEGRT 119
            .|  ..|| |.:::::::                 .:.::.::..|.|       .|:..|..:.
  Fly   194 EP--PPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRDQGACISVLAVKV 256

Mouse   120 -FVSQPGFVGLEGLPYFLEEPE---------------DKAVPANTPFNL------------SCQA 156
             :::.|...  |...:|.|.|.               |.|.|..||..|            .|:.
  Fly   257 YYITCPAVT--ENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRC 319

Mouse   157 QGPPEPVTLLWLQDAVPLAPVTGHSSQHSLQTP-----GLNKTSSFSCEAHNAKGV----TTSRT 212
            :...||..........||.  |..|.:.:..||     ..:||.|..|:.  |.|.    ...|.
  Fly   320 KAGYEPNYTNKTCTECPLG--TFKSPEVTKCTPCPPNSNASKTGSPFCKC--ASGFYRHPNDGRH 380

Mouse   213 ATITVLPQRPHHLHVVSRQPTELEVAWTPGLSG----------------IYPLTHCNLQAVLSDD 261
            ......|..|.:|.::....|...::|:.....                :|.: .||   :.|.:
  Fly   381 MPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI-KCN---ICSPN 441

Mouse   262 GVGIWLGKSDPPEDPLTLQVSVPPHQLRLEKLLPHTPYHIRISCSSSQGPSPWTHW--------- 317
            .|      .:|..|...      ..::.|..|.|.|.|.::|...:|.     :|.
  Fly   442 VV------YNPSTDTFN------ETKITLTNLEPVTTYTVQIHAINSV-----SHINEFKRHSNE 489

Mouse   318 ------------------LPVE-------------TTEGVPLGPPEN--VSAMRNGSQVLVRWQE 349
                              :|::             |||.|.|....|  :.|:.|....| .|.:
  Fly   490 SSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADL-EWDK 553

Mouse   350 P---RVPLQGTLLGYRLAYRGQDTPEVLMDI----GL-TREVTLELRGDRPVANLTVSVTAYTSA 406
            |   ..||:        .|..:..|:|.:|.    .| |:|....:.|..........|...|:.
  Fly   554 PVQSDFPLE--------FYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNN 610

Mouse   407 GDGPWSLPVPLEPWRPGQGQPLHHLVSEPPPRAFSWPWWYVLLGALVAAACVLILALFLV----- 466
            |.|.:|..:..:..     |.:..:..:.....|       :.||:|..  ||.|.:|::
  Fly   611 GFGSYSNMIYAQTL-----QSVGSVYDDSVQIRF-------IAGAIVTG--VLFLVIFIIATVYF 661

Mouse   467 ----HR---RKKETRY---------GEV----FEPTVERGELVVR---YRVRKSYSRRTTEATLN 508
                |:   .||.|.:         .||    ..|.|::..|.|.   :...:||....|....|
  Fly   662 MRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPN 726

Mouse   509 SLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN------QDDSILKVAVKTMKIAI 567
                 :.::|..|:  :|.:.:.:...:|.||||.|..|:|.      ||   :.||:||:|...
  Fly   727 -----QAIREFARE--IDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQD---IDVAIKTLKPGS 781

Mouse   568 CTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVIL-PFMKHGDLHSFLLYSRL 631
            ..::.. |||:||..|.:||||||:.|.||..:.:       ||:|: .:|::|.|.:||   |:
  Fly   782 SEKARC-DFLTEASIMGQFDHPNVIYLQGVVTRSN-------PVMIITEYMENGSLDTFL---RV 835

Mouse   632 GDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDY 696
            .|..  ..|..|:..:..|||||.|||...::||||||||.::|..:...:||||||::|.|...
  Fly   836 NDGK--FQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD 898

Mouse   697 YRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNR 761
            ....|..|:||:|.|.|::|.|.:||.|||||:||.:||:.:.|:.||....|.::...:.:|.|
  Fly   899 AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYR 963

Mouse   762 LKQPVDCLDGLYALMSRCWELNPRDRPSFAELREDLENTLKALPPAQEPDEILYV--NMDEGGSH 824
            |..|:||.:.||.||..||:.....||:||.:...|:|.      |::|..:|..  :.:..|:|
  Fly   964 LPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNL------ARQPQSLLTTRPSPESDGNH 1022

Mouse   825 L 825
            :
  Fly  1023 I 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axl	NP_033491.2	Interaction with GAS6. /evidence=ECO:0000250	19..86		14/70 (20%)
		Ig	47..114	CDD:319273	15/105 (14%)
		Ig	135..216	CDD:386229	25/116 (22%)
		FN3	219..322	CDD:238020	21/158 (13%)
		fn3	329..411	CDD:365830	20/91 (22%)
		PTKc_Axl	529..805	CDD:270660	109/282 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	820..846		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..888
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	21/132 (16%)
		FN3	387..476	CDD:238020	18/104 (17%)
		FN3	536..623	CDD:238020	21/95 (22%)
		EphA2_TM	644..736	CDD:291255	21/100 (21%)
		PTKc_EphR	736..1002	CDD:270629	109/281 (39%)
		Pkinase_Tyr	741..999	CDD:285015	107/273 (39%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910