DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GBX1 and ftz

DIOPT Version :9

Sequence 1:	NP_001092304.1	Gene:	GBX1 / 2636	HGNCID:	4185	Length:	363	Species:	Homo sapiens
Sequence 2:	NP_477498.1	Gene:	ftz / 40834	FlyBaseID:	FBgn0001077	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	94/387 - (24%)
Similarity:	126/387 - (32%)	Gaps:	152/387 - (39%)

- Green bases have known domain annotations that are detailed below.

Human    56 VLPQALAPAPLPAGLPPLAPLASFAGRLTNTFCAGLGQAV---PSMV--ALTTALPSFAEPPDAF 115
            |..|.:.|.. |...||.|     ..|......|.:..||   ||.:  .||..:......||.|
  Fly    69 VTTQTVPPVQ-PTTPPPKA-----TKRKAEDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYF 127

Human   116 YGPQELAAAAAAAAATAARNNPEPGGRRPEGGLEADELLPAREKVAEPPPP---------PPPHF 171
            |...|....|.|.:.                            ||...|.|         |.|..
  Fly   128 YTTVEQVKKAPAVST----------------------------KVTASPAPSYDQEYVTVPTPSA 164

Human   172 SETFPSLPAEGKVYSSDEEKLEASAGDPAGSEQEEEGSGGDSEDDGFLDSSAGGPGALLGPKPKL 236
            ||....|    .|||...:..:...||                   |.......|.:|    |.|
  Fly   165 SEDVDYL----DVYSPQSQTQKLKNGD-------------------FATPPPTTPTSL----PPL 202

Human   237 KGSLGT-----GAEEGAPVTAG-----VTAPGG------------------KSRRRRTAFTSEQL 273
            :| :.|     |.:..:.|:..     ||||.|                  .|:|.|..:|..|.
  Fly   203 EG-ISTPPQSPGEKSSSAVSQEINHRIVTAPNGAGDFNWSHIEETLASDCKDSKRTRQTYTRYQT 266

Human   274 LELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIK----------AG------ 322
            ||||||||..:|::...|..||:||.|||.|:||||||||.|.|:.:          ||
  Fly   267 LELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDRTLDSSPEHCGAGYTAMLP 331

Human   323 ----NVSSRSGEPVRNPKIVVPIPVH----------------------VNRFAVRSQHQQME 358
                ..::.:|.|      .||:|::                      :|.:..:..|||.:
  Fly   332 PLEATSTATTGAP------SVPVPMYHHHQTTAAYPAYSHSHSHGYGLLNDYPQQQTHQQYD 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBX1	NP_001092304.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..265		30/173 (17%)
		Homeobox	264..317	CDD:306543	30/52 (58%)
ftz	NP_477498.1	FTZ	1..248	CDD:281812	50/240 (21%)
ftz	NP_477498.1	Homeobox	257..310	CDD:278475	30/52 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810