DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GBX1 and unpg

DIOPT Version :9

Sequence 1:	NP_001092304.1	Gene:	GBX1 / 2636	HGNCID:	4185	Length:	363	Species:	Homo sapiens
Sequence 2:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	452	Identity:	155/452 - (34%)
Similarity:	186/452 - (41%)	Gaps:	168/452 - (37%)

- Green bases have known domain annotations that are detailed below.

Human    25 FSIDSLIG---------PPPPR---------------------SGHLLYTGYPMFMPY------- 52
            |||:|||.         |.||.                     |..|..|.:|::.|:
  Fly    31 FSIESLIANQTPATATPPSPPEERDQEQEAEQEQELSARAMVASSALGLTQFPLYNPWLHGYFAQ 95

Human    53 -----RPLV-----LPQALAPAPLPAGLPPLAPLASFAGRLTNTFCAGLGQAVPS-------MVA 100
                 ..|:     ||.  :||..||...|.|                  ||.|.       ..|
  Fly    96 NHERLTHLIAGGCYLPS--SPAGHPAAQQPQA------------------QAQPQPPPPHPPTHA 140

Human   101 LTTAL-PSFAEPPDAFYGPQELAAAAAAAAATAARNNPE--------------------PGGRRP 144
            |...| |:...|.|..:.|...|||..|....:.|...|                    ..||..
  Fly   141 LEKQLPPTLPHPLDTRFLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMH 205

Human   145 EGGLEADELLPAREKVAEPPPPPPPHFSETFPSLPAEGKVYSSDEEKLEASAGDPAGSEQEEEGS 209
            |     |:..|...::.| |.||..|      |.||:...:|..|..|:      .|.:::.|.|
  Fly   206 E-----DQANPGMAQLQE-PTPPQAH------SSPAKSGSHSPMEPALD------VGMDEDFECS 252

Human   210 GGDSED----------DGFLDSSAGGP---------------------GALLGPKPKLKGSLGTG 243
            |....|          :|.:|.|..|.                     |.:.|     |.|.|.|
  Fly   253 GDSCSDISLTMSPRNYNGEMDKSRNGAYTNSDSEDCSDDEGAQSRHEGGGMGG-----KDSQGNG 312

Human   244 AEEGAPVTAGVTAPGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIW 308
            :...:           ||||||||||||||||||:|||.|||||||||||||.:|||||||||||
  Fly   313 SSSNS-----------KSRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQVKIW 366

Human   309 FQNRRAKWKRIKAGNVS---SRSGEPVRNPKIVVPIPVHVNRFAVRSQHQQMEQ----GARP 363
            ||||||||||:|||..|   .|:| .....|||||||||||||||||||||:|:    |.:|
  Fly   367 FQNRRAKWKRVKAGLTSHGLGRNG-TTSGTKIVVPIPVHVNRFAVRSQHQQLEKMCLSGPKP 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBX1	NP_001092304.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..265		37/187 (20%)
		Homeobox	264..317	CDD:306543	48/52 (92%)
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	46/50 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160115
Domainoid	1	1.000	108	1.000	Domainoid score	I6426
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4061
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003648
OrthoInspector	1	1.000	-	-		otm42097
orthoMCL	1	0.900	-	-		OOG6_106620
Panther	1	1.100	-	-	LDO	PTHR24334
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4817
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780