DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ing1 and MESR4

DIOPT Version :9

Sequence 1:	NP_036049.2	Gene:	Ing1 / 26356	MGIID:	1349481	Length:	279	Species:	Mus musculus
Sequence 2:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster

Alignment Length:	300	Identity:	58/300 - (19%)
Similarity:	85/300 - (28%)	Gaps:	150/300 - (50%)

- Green bases have known domain annotations that are detailed below.

Mouse   108 SHVELFEAHQDISDGTGGSGKAGQ-------------------DKSKSEAIT-------QADKPN 146
            :|.:|..:...:|:|:..|...||                   |::.|..:.       |..||.
  Fly  1858 THRQLQSSMTRMSEGSSCSDADGQLKRSKRQRRPNKFYGYTSDDENMSAVLAPPLQVGMQLIKPQ 1922

Mouse   147 -------------NKRSRRQRNNENRENASNNHDHDDITSGTPKEKKAKT------SKKKKRSK- 191
                         ....:|.|||.|..:..::|.:..:...:.|..|.::      |:..||.|
  Fly  1923 PPPQLTWAKEDLPTPPKQRNRNNNNSSHHHHSHSNGGMAGSSRKRSKQRSLFGAGGSRPAKRHKP 1987

Mouse   192 -------------------------------AKAEREAS----------------------PADL 203
                                           :..:.||.                      |..|
  Fly  1988 DPNDHLPPIPTLKIRPSLLPTTAPPSDSSESSSDDEEAEVNVTSVVPTPQPAPPPVLPTPLPVAL 2052

Mouse   204 PIDP---------NEP------------------------------------------TYCLCNQ 217
            |:.|         |:|                                          .||.|..
  Fly  2053 PVPPPPPPAATAFNQPIPPALLPNPGFATLQYFKANNIRYPIRPPAGARLAREGESVYCYCRCPY 2117

Mouse   218 VSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCR 257
            ....|||.||.|.|.||||||.|||:...|:|||:|.:||
  Fly  2118 DEVSEMIACDGDNCLIEWFHFECVGIMVAPQGKWFCAECR 2157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ing1	NP_036049.2	ING	15..111	CDD:315637	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..206		27/189 (14%)
		PHD_ING1_2	212..256	CDD:277059	24/43 (56%)
		PBR. /evidence=ECO:0000250\|UniProtKB:Q9H160	262..279
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368
		C2H2 Zn finger	1295..1315	CDD:275370
		C2H2 Zn finger	1323..1341	CDD:275370
		PHD_ING	2110..2156	CDD:276980	24/45 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910