Protein Alignment GBP3 and gbp2

DIOPT Version :10

• Sequence 1: NP_060754.2
• Gene: GBP3 / 2635
• HGNCID: 4184
• Length: 595
• Species: Homo sapiens
• Sequence 2: NP_001072267.1
• Gene: gbp2 / 779720
• XenbaseID: XB-GENE-5828806
• Length: 591
• Species: Xenopus tropicalis
• Alignment Length: 581
• Identity: 295/581 - (50%)
• Similarity: 399/581 - (68%)
• Gaps: 3/581 - (0%)

Human     1 MAPEIHMTGPMCLIENTN-GELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKG 64
            |:.:|||..|:|||||.| .|.|.|.||.:|||.||.|||||||||.||||||||||||||...|
 Frog     1 MSAQIHMKYPICLIENRNSNEFVINTEAEQILSQITDPVVVVAIVGKYRTGKSYLMNKLAGSKTG 65

Human    65 FSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYN 129
            |:||||::|.||||||||||||.:|.||||||||||||||:|||::||.|||:|||||||.||||
 Frog    66 FALGSTIQSKTKGIWMWCVPHPCQPSHTLVLLDTEGLGDVEKGDSKNDGWIFSLAVLLSSNLVYN 130

Human   130 SMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPL 194
            |||||:.|:|:||:||||||:.|:.||:|.|.::| |.:|...||.|.|.:|||||.||.||:.:
 Frog   131 SMGTIDHQSMEQLHYVTELTNLIKIKSNPKEGKDE-SGEFKRIFPSFTWCVRDFSLILELDGKKV 194

Human   195 TPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPE 259
            |.|:||..||:|.:||.:|.::|||||.||..:|...||||||.|...|.|.:||:||::.|:..
 Frog   195 TEDDYLMNSLRLKKGTDRKTQDFNLPRECILHYFHSHKCFVFDQPTSSRNLHRLEELQEQNLEET 259

Human   260 FVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIENSA 324
            ||:|...||.||..:...|||.||:.|.|..|..|...||..|..|.:||||||:|||:.|||:.
 Frog   260 FVEQAQKFCGYIHRDGIAKTLPGGLLVTGRMLAHLTSLYIETIMSGSVPCMENAILALSVIENTG 324

Human   325 AVQKAIAHYDQQMGQKV-QLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDK 388
            |||.|:|.|:..|.:.: :.|.|||||.|.||:.||:||.||::|.||.|.:..|||:....||.
 Frog   325 AVQDALAKYETCMNEHLPRFPTETLQEFLHLHQGSEKEALEVFLKRSFNDENQDFQKEFKNLLDN 389

Human   389 KRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGI 453
            |..:|.::|:..|::||..::|.:...||:.:..|.:|||||:.||:::...:.::|...|.||:
 Frog   390 KMKEFSERNERESTERCQTIIQKLSESLEQRISQGEFSKPGGHKLFLKEKMTIMEEYNTTPHKGL 454

Human   454 QAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEK 518
            ::.|:||.::.:|::...||||.|:.||.|||||.....:...|:...:::||.:...|:.||.:
 Frog   455 KSLEVLQEFISNKKATEAAILQADESLTAKEKEIAESQAETAEAERQRQILEEKEKYLQESMENQ 519

Human   519 EKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQK 579
            :||:::|.|.|.||||.:|.:|:.|..:.:..|||||..:|....|.:...||.||..|.:
 Frog   520 KKSFEQHEKMLIEKMEADRQKLIAENGRVIAQKLQEQNAMLTAGFQSKVNDLQREIADLNR 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP3	NP_060754.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..309		185/308 (60%)
		GBP	18..280	CDD:460516	163/262 (62%)
		GBP_C	282..574	CDD:460721	117/292 (40%)
gbp2	NP_001072267.1	GBP	20..280	CDD:460516	162/260 (62%)
		GBP_C	282..579	CDD:460721	119/296 (40%)