DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP3 and atl

DIOPT Version :9

Sequence 1:	NP_060754.2	Gene:	GBP3 / 2635	HGNCID:	4184	Length:	595	Species:	Homo sapiens
Sequence 2:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	106/478 - (22%)
Similarity:	188/478 - (39%)	Gaps:	85/478 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     7 MTGPMCLIENTNGE--LVANPEAL-KIL---SAITQPVVVVAIVGLYRTGKSYLM---------- 55
            |.|....:.|.:.|  .|.|.:|| ::|   ....:.|.||::.|.:|.|||:|:
  Fly     1 MGGSAVQVINASEEHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSK 65

Human    56 -------NKLAGKN---KGFSLGSTVKSHTKGIWMW----CVPHPKKPEHTLVLLDTEGLGDVKK 106
                   :.|.|::   :|||.....:..|.||.||    ...:|...:..::||||:|..| .:
  Fly    66 YVHHDATDWLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFD-SQ 129

Human   107 GDNQNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVS 171
            ...::.:.:|.|:.:|||..:||....|.:..:..|...||......:.:....
  Fly   130 STVRDCATVFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKP----------- 183

Human   172 FFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVF 236
             |....:.:||:|...||:...|..|:.|:..|::   :.::.......|..|...|.:..||:
  Fly   184 -FQRLQFLVRDWSFPYEAEYGALGGDKILKRRLEV---SDKQHPELQSLRRHISSCFTEVACFL- 243

Human   237 DLPIHRRKLAQLEK----LQDEELDPEFVQQVADFCSYIFS--NSKTKTLSGGIKVNGPRLESLV 295
             :|.....:|...|    |||  :.|||...:......:.:  |...|.:||. :|....|....
  Fly   244 -MPHPGLNVATNPKFDGRLQD--ITPEFKSSLRSLVPMLLAPDNLVYKEISGQ-RVRARDLIQYF 304

Human   296 LTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQM-----GQKVQLPAETLQ------ 349
            .:|:|.....:||..::.::|.|:..:..||..|...|.|.|     |.:..|....||
  Fly   305 QSYMNIYKGNELPEPKSMLVATAEANHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHLRV 369

Human   350 ------ELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSAL 408
                  :.....::...|.||.:.|....|::.:|....|.  ::.::.|......|....|:.:
  Fly   370 KDKALFQFAAKRKMGGEEFTEKFRKQLEDDLEEVFTNYQAH--NESKNIFKAARTPAVYFACAVI 432

Human   409 LQVIFSPLEEEVKAGIYSKPGGY 431
            :.::         :||:...|.|
  Fly   433 MYIL---------SGIFGLVGLY 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP3	NP_060754.2	GTPase domain (Globular). /evidence=ECO:0000250	1..309		79/337 (23%)
		GBP	18..280	CDD:280433	69/297 (23%)
		GBP_C	282..574	CDD:202427	33/167 (20%)
		GBP_C	288..574	CDD:293879	31/161 (19%)
		coiled coil	547..558	CDD:293879
atl	NP_001287506.1	GBP	14..289	CDD:280433	68/294 (23%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	28/142 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750