Protein Alignment GBP3 and Gbp1

DIOPT Version :9

• Sequence 1: NP_060754.2
• Gene: GBP3 / 2635
• HGNCID: 4184
• Length: 595
• Species: Homo sapiens
• Sequence 2: XP_017446842.2
• Gene: Gbp1 / 304266
• RGDID: 1311877
• Length: 780
• Species: Rattus norvegicus
• Alignment Length: 603
• Identity: 410/603 - (67%)
• Similarity: 495/603 - (82%)
• Gaps: 11/603 - (1%)

Human     1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGF 65
            |..:|||.||:|||||..|:|.||.:||:||||||||||||||||||||||||||||||||..||
  Rat     3 MTLQIHMPGPVCLIENVKGQLRANQKALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKTGF 67

Human    66 SLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNS 130
            ||||||::|||||||||||||.|..|.||||||||||||:|||||||.|||:||:|||||.||||
  Rat    68 SLGSTVQAHTKGIWMWCVPHPNKANHMLVLLDTEGLGDVEKGDNQNDCWIFSLAILLSSTFVYNS 132

Human   131 MGTINQQAMDQLYYVTELTHRIRSKSSPDENEN-EDSADFVSFFPDFVWTLRDFSLDLEADGQPL 194
            ||.|||||||||:||||||.|||::||||:::. ||||:||||||||||||||.:|.:|.||..:
  Rat   133 MGAINQQAMDQLHYVTELTDRIRARSSPDQDDGVEDSAEFVSFFPDFVWTLRDMTLKMEVDGLQV 197

Human   195 TPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPE 259
            |.|||||.||||.:|:|::.:.:|||||||||||||||||||..|...::|:|||.||:.|:|.|
  Rat   198 TADEYLEISLKLKEGSSKEVEKYNLPRLCIRKFFPKKKCFVFYPPTEWKRLSQLETLQENEIDSE 262

Human   260 FVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIENSA 324
            |:||||:||.|:|...|.|||.|||.|||||||:|||||::|||.|||||||||||.||||||||
  Rat   263 FLQQVAEFCLYVFKECKAKTLPGGIIVNGPRLETLVLTYLSAISSGDLPCMENAVLTLAQIENSA 327

Human   325 AVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKK 389
            ||:|||.||||||.|:||||.|||||||||||..||||.|::::.||||.||.||.||.::|:::
  Rat   328 AVEKAITHYDQQMSQRVQLPTETLQELLDLHRTCEREAIEIFLRVSFKDEDHSFQMKLGSRLEER 392

Human   390 RDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQ 454
            .:||||:|.|.||:||.||||.||.||||.||.|.|||||||.||:|:.|.|::||..:|:||:|
  Rat   393 WNDFCKRNMEVSSNRCWALLQDIFRPLEESVKQGTYSKPGGYYLFVQETQRLKEKYQGQPKKGLQ 457

Human   455 AEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKE 519
            |:|:||.||:|||::|.|||||||.|||||||||||..|||||||:||::||.|.|.:::||:||
  Rat   458 ADEVLQKYLQSKEAITTAILQTDQSLTEKEKEIEVERKKAESAQAAAKLLEETQKKNEKLMEQKE 522

Human   520 KSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKK- 583
            :|||||:||||||||.:|.||..|||:.|:.|||||.::|:|..:.||.:||.|::.::|..|:
  Rat   523 RSYQEHMKQLTEKMENDRIQLKAEQERILSLKLQEQKQLLQEGFREESRKLQEEMKNVEKRYKET 587

Human   584 ---------KTKRYMSHK 592
                     |||..|..|
  Rat   588 MDHMKAESSKTKEEMQRK 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP3	NP_060754.2	GTPase domain (Globular). /evidence=ECO:0000250	1..309		226/308 (73%)
		GBP	18..280	CDD:280433	192/262 (73%)
		GBP_C	282..574	CDD:202427	197/291 (68%)
		GBP_C	288..574	CDD:293879	192/285 (67%)
		coiled coil	547..558	CDD:293879	6/10 (60%)
Gbp1	XP_017446842.2	GBP	20..283	CDD:308078	192/262 (73%)
		GBP_C	285..581	CDD:397124	198/295 (67%)
		PTZ00121	<439..773	CDD:173412	93/167 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	431	1.000	Domainoid score	I9637
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	860	1.000	Inparanoid score	I6811
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55037
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	1	1.000	-	-		otm52323
orthoMCL	1	0.900	-	-		OOG6_100467
Panther	1	1.100	-	-	LDO	PTHR10751
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980