Protein Alignment GBP3 and Gbp2

DIOPT Version :10

• Sequence 1: NP_060754.2
• Gene: GBP3 / 2635
• HGNCID: 4184
• Length: 595
• Species: Homo sapiens
• Sequence 2: NP_034390.1
• Gene: Gbp2 / 14469
• MGIID: 102772
• Length: 589
• Species: Mus musculus
• Alignment Length: 579
• Identity: 390/579 - (67%)
• Similarity: 466/579 - (80%)
• Gaps: 0/579 - (0%)

Human     1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGF 65
            ||.||||:.||||||||..:||.|.|||:||||||||||||||||||||||||||||||||..||
Mouse     1 MASEIHMSEPMCLIENTEAQLVINQEALRILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKRTGF 65

Human    66 SLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNS 130
            ||||||:||||||||||||||||...||||||||||.||:|||||||.|||.||||||||.:|||
Mouse    66 SLGSTVQSHTKGIWMWCVPHPKKAGQTLVLLDTEGLEDVEKGDNQNDCWIFALAVLLSSTFIYNS 130

Human   131 MGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLT 195
            :|||||||||||:||||||..|:||||||::..:|||:||.|||.||||||||||:||.:|:|:|
Mouse   131 IGTINQQAMDQLHYVTELTDLIKSKSSPDQSGVDDSANFVGFFPTFVWTLRDFSLELEVNGKPVT 195

Human   196 PDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEF 260
            .|||||:||.|.:|..:|.|:||.|||||||||||:|||:||.|..|::|::||.|::|||..||
Mouse   196 SDEYLEHSLTLKKGADKKTKSFNEPRLCIRKFFPKRKCFIFDRPAQRKQLSKLETLREEELCGEF 260

Human   261 VQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAA 325
            |:|||:|.|||.|.|..|||.|||.||||||:|||.||:.|||.|.|||||:|||.|||||||||
Mouse   261 VEQVAEFTSYILSYSSVKTLCGGIIVNGPRLKSLVQTYVGAISNGSLPCMESAVLTLAQIENSAA 325

Human   326 VQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKR 390
            |||||.||::||.||:|:|.|||||||||||..|.||.||::||||||||..||.:|...|..||
Mouse   326 VQKAITHYEEQMNQKIQMPTETLQELLDLHRPIESEAIEVFLKNSFKDVDQKFQTELGNLLVAKR 390

Human   391 DDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQA 455
            |.|.|:|.:.||.|||.||:.||.|||||||.|.:||||||.||:|..|:|||||.:.|.||:||
Mouse   391 DAFIKKNMDVSSARCSDLLEDIFGPLEEEVKLGTFSKPGGYYLFLQMRQELEKKYNQAPGKGLQA 455

Human   456 EEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEK 520
            |.:|:.|..||..|.:.:|||||.|||..||:|.|..|||:|:|:.:.:|:.|.:::.||::|||
Mouse   456 EAMLKNYFDSKADVVETLLQTDQSLTEAAKEVEEERTKAEAAEAANRELEKKQKEFELMMQQKEK 520

Human   521 SYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQK 579
            |||||||:|||||:.|:.|||.|||..:.:||:||.:.|||..:.||.:|..||..|::
Mouse   521 SYQEHVKKLTEKMKDEQKQLLAEQENIIAAKLREQEKFLKEGFENESKKLIREIDTLKQ 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP3	NP_060754.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..309		228/307 (74%)
		GBP	18..280	CDD:460516	193/261 (74%)
		GBP_C	282..574	CDD:460721	178/291 (61%)
Gbp2	NP_034390.1	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..309		228/307 (74%)
		GBP	18..280	CDD:460516	193/261 (74%)
		GBP_C	282..578	CDD:460721	180/295 (61%)