DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP3 and Gbp2b

DIOPT Version :9

Sequence 1:	NP_060754.2	Gene:	GBP3 / 2635	HGNCID:	4184	Length:	595	Species:	Homo sapiens
Sequence 2:	NP_034389.2	Gene:	Gbp2b / 14468	MGIID:	95666	Length:	589	Species:	Mus musculus

Alignment Length:	578	Identity:	386/578 - (66%)
Similarity:	480/578 - (83%)	Gaps:	0/578 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGF 65
            ||.||||.||:|||:|:..:|....|||.|||||..|||||||||.|.|||||||||||||.|||
Mouse     1 MASEIHMKGPVCLIKNSGEQLEVYQEALDILSAIQNPVVVVAIVGFYHTGKSYLMNKLAGKQKGF 65

Human    66 SLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNS 130
            ||||||:||||||||||:|||:||||||||||||||.|::|||||||.|||.||||||||.:|||
Mouse    66 SLGSTVQSHTKGIWMWCMPHPEKPEHTLVLLDTEGLKDMQKGDNQNDCWIFALAVLLSSTFIYNS 130

Human   131 MGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLT 195
            :|||||||||||:||||||..|:||||||:::.::||:||.|||.|||||||||||||.||:.:|
Mouse   131 IGTINQQAMDQLHYVTELTDLIKSKSSPDQSDVDNSANFVGFFPIFVWTLRDFSLDLEFDGESIT 195

Human   196 PDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEF 260
            ||||||.||.|.:||.:..|.||:|||||||||||:|||:||.|..|::|::||.:|:::|:.||
Mouse   196 PDEYLETSLALRKGTDENTKKFNMPRLCIRKFFPKRKCFIFDRPGDRKQLSKLEWIQEDQLNKEF 260

Human   261 VQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAA 325
            |:|||:|.|||||.|..|||||||.||||||:|||.||::||..|:|||||||||.|||||||||
Mouse   261 VEQVAEFTSYIFSYSGVKTLSGGITVNGPRLKSLVQTYVSAICSGELPCMENAVLTLAQIENSAA 325

Human   326 VQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKR 390
            |||||.:|::||.||:.:|.|||||||||||..||||.||:|||||||||..||::|.|||:.||
Mouse   326 VQKAITYYEEQMNQKIHMPTETLQELLDLHRTCEREAIEVFMKNSFKDVDQKFQEELGAQLEAKR 390

Human   391 DDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQA 455
            |.|.|:|.:.||..||.||:.:|:.||||||.|.:.|||||.||:|:.|:|||||.:.|.||:||
Mouse   391 DAFVKKNMDMSSAHCSDLLEGLFAHLEEEVKQGTFYKPGGYYLFLQRKQELEKKYIQTPGKGLQA 455

Human   456 EEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEK 520
            |.:|:.|.:|||.:.|.:|:.||.||||||:||:|.:|||:|:|:.:.:.|||.|::.:||:||:
Mouse   456 EVMLRKYFESKEDLADTLLKMDQSLTEKEKQIEMERIKAEAAEAANRALAEMQKKHEMLMEQKEQ 520

Human   521 SYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQ 578
            |||||:||||||||:||.:|:.||::.::.|||||.|:||:..|.||.||:.||:|::
Mouse   521 SYQEHMKQLTEKMEQERKELMAEQQRIISLKLQEQERLLKQGFQNESLQLRQEIEKIK 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP3	NP_060754.2	GTPase domain (Globular). /evidence=ECO:0000250	1..309		221/307 (72%)
		GBP	18..280	CDD:280433	188/261 (72%)
		GBP_C	282..574	CDD:202427	180/291 (62%)
		GBP_C	288..574	CDD:293879	175/285 (61%)
		coiled coil	547..558	CDD:293879	5/10 (50%)
Gbp2b	NP_034389.2	GBP	19..280	CDD:308078	188/260 (72%)
Gbp2b	NP_034389.2	GBP_C	282..578	CDD:308475	183/295 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	409	1.000	Domainoid score	I10988
eggNOG	1	0.900	-	-		E1_KOG2037
HGNC	1	1.500	-	-
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H137233
Inparanoid	1	1.050	842	1.000	Inparanoid score	I7422
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55037
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	1	1.000	-	-		mtm9915
orthoMCL	1	0.900	-	-		OOG6_100467
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.280