DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GBP3 and si:dkeyp-30d6.2

DIOPT Version :9

Sequence 1:	NP_060754.2	Gene:	GBP3 / 2635	HGNCID:	4184	Length:	595	Species:	Homo sapiens
Sequence 2:	NP_001353308.1	Gene:	si:dkeyp-30d6.2 / 100322630	ZFINID:	ZDB-GENE-141222-83	Length:	378	Species:	Danio rerio

Alignment Length:	375	Identity:	201/375 - (53%)
Similarity:	264/375 - (70%)	Gaps:	7/375 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     7 MTGPMCLIE-NTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSLGST 70
            |..|:|||. :::|:|...|.||::|..|.|||||||:|||||||||||||.||||..||:||.|
Zfish     1 MDKPVCLINTDSDGKLYVQPAALQVLQQIQQPVVVVAVVGLYRTGKSYLMNHLAGKQTGFALGGT 65

Human    71 VKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTIN 135
            ::|.||||||||||||.|...|||||||||||||:|||:::|:.||.|||||||||||||.||||
Zfish    66 IESKTKGIWMWCVPHPTKTGTTLVLLDTEGLGDVEKGDSKHDTNIFCLAVLLSSTLVYNSRGTIN 130

Human   136 QQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYL 200
            .:|:::|.||||||..|:.|||  :.:.:||.:||.|||.|:|::|||:|:.:.||:..|.||||
Zfish   131 NRAIEELQYVTELTECIKVKSS--DEDVDDSTEFVKFFPSFIWSVRDFTLERKIDGKDATEDEYL 193

Human   201 EYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVA 265
            |::|||..|||:|..:|||||.||:||||.:.||.|..|....|::.||.|...:|..||::...
Zfish   194 EFALKLKPGTSKKITSFNLPRECIQKFFPTRTCFTFPFPTAPEKMSTLESLSPADLSTEFLEVTK 258

Human   266 DFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAI 330
            .||.::|..|:.|.|..|..|.|..|.:|...|:|.||.|.:||:||||:|:|||||.||.|:.:
Zfish   259 RFCKFVFDKSEVKRLKDGHTVTGRVLGNLTKMYVNTISSGAVPCLENAVIAMAQIENVAATQEGL 323

Human   331 AHYDQQMGQ-KVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVD--HL 377
            ..|.:.|.: |...|.| |:::...|:....:||:.:|..||||.|  ||
Zfish   324 EVYQRGMEKVKCSFPLE-LEQVSSEHQRLSSKATQAFMARSFKDTDGKHL 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP3	NP_060754.2	GTPase domain (Globular). /evidence=ECO:0000250	1..309		169/302 (56%)
		GBP	18..280	CDD:280433	153/261 (59%)
		GBP_C	282..574	CDD:202427	42/99 (42%)
		GBP_C	288..574	CDD:293879	40/93 (43%)
		coiled coil	547..558	CDD:293879
si:dkeyp-30d6.2	NP_001353308.1	P-loop_NTPase	13..273	CDD:328724	153/261 (59%)
si:dkeyp-30d6.2	NP_001353308.1	GBP_C	281..>376	CDD:328214	40/93 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920