Protein Alignment GBP3 and gbp6

DIOPT Version :10

• Sequence 1: NP_060754.2
• Gene: GBP3 / 2635
• HGNCID: 4184
• Length: 595
• Species: Homo sapiens
• Sequence 2: NP_001120628.1
• Gene: gbp6 / 100145795
• XenbaseID: XB-GENE-6050518
• Length: 628
• Species: Xenopus tropicalis
• Alignment Length: 583
• Identity: 275/583 - (47%)
• Similarity: 403/583 - (69%)
• Gaps: 6/583 - (1%)

Human     1 MAPEIHMTGPMCLIENTNG----ELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGK 61
            |:..:.|:.|:|||||.|.    :||.|.:|::||..||:|||.|||||.||||||||||||||.
 Frog     1 MSRGVVMSHPVCLIENQNTPEGYKLVINQKAVQILEDITEPVVPVAIVGKYRTGKSYLMNKLAGS 65

Human    62 NKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTL 126
            |.||:||||::|.||||||||||||.||.||||||||||||||:|||.:||||:|:|||||||||
 Frog    66 NDGFALGSTIQSKTKGIWMWCVPHPHKPGHTLVLLDTEGLGDVEKGDRKNDSWVFSLAVLLSSTL 130

Human   127 VYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADG 191
            ||||:|||:|:::::|:||||||.||:.|:. ..|::::||:|...||.|:|.:|||:|.||.:|
 Frog   131 VYNSVGTIDQESLEKLHYVTELTERIKLKAK-TSNDDDESAEFKRTFPSFIWCVRDFTLKLEQEG 194

Human   192 QPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEEL 256
            :.:|.||||:.:|.|..|.|:..:.:|.||.||..||...|||||:.|.....|.:||:|.:.:|
 Frog   195 KQITEDEYLQMALNLKPGFSKAAREYNFPRECITHFFHSHKCFVFERPASTEDLQRLEELSESQL 259

Human   257 DPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIE 321
            :|.||:|...||.::|:||:||||:||..|.|..|.:|.:||:.:|..|.:||||||||||||||
 Frog   260 EPRFVKQAHRFCDFVFNNSQTKTLAGGHCVTGRMLGTLAVTYVESIRSGSVPCMENAVLALAQIE 324

Human   322 NSAAVQKAIAHYDQQMGQ-KVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQ 385
            |:||:|||::.|:.:|.| :...|.||..|.|......|::|.:|:|..||||....:|.||...
 Frog   325 NTAAIQKALSVYEAEMKQAEGTFPTETQDEFLSKQTQCEKKAVKVFMDRSFKDDKREYQGKLMGD 389

Human   386 LDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPR 450
            |.:|..:|.|:|:|||..:|..||||:.:.||:.:|..::|||||:..::::.|.:...|...|.
 Frog   390 LQQKHQEFAKRNEEASIHKCQDLLQVLSANLEKGIKNVVFSKPGGHKQYLKEKQKIMDTYNNSPG 454

Human   451 KGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMM 515
            |||:|..:||.:::.|:::...:||.|:.||:::||:|.|.:|.|:|:...:..:|...:.::..
 Frog   455 KGIKAALVLQQFIEGKKNIEMTVLQADESLTKQQKEMEEEKMKKEAAEKKLQEEKENARQLERTR 519

Human   516 EEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQ 578
            :|:.:..::....|.||:|.||..||:|.|..:..|::|:.::.:|....::..|..::..||
 Frog   520 KEQTQRLEQQAIMLKEKLEEERHMLLKENEWMIKEKMKEREKLAQEGLHNKAGMLGEQVNALQ 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP3	NP_060754.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..309		175/311 (56%)
		GBP	18..280	CDD:460516	155/265 (58%)
		GBP_C	282..574	CDD:460721	108/292 (37%)
gbp6	NP_001120628.1	GBP	25..283	CDD:460516	154/258 (60%)
		GBP_C	291..582	CDD:293879	105/290 (36%)
		coiled coil	551..562	CDD:293879	2/10 (20%)
		coiled coil	571..582	CDD:293879	1/10 (10%)