Protein Alignment GBP3 and gbp5

DIOPT Version :10

• Sequence 1: NP_060754.2
• Gene: GBP3 / 2635
• HGNCID: 4184
• Length: 595
• Species: Homo sapiens
• Sequence 2: NP_001120244.2
• Gene: gbp5 / 100145295
• XenbaseID: XB-GENE-5756296
• Length: 636
• Species: Xenopus tropicalis
• Alignment Length: 578
• Identity: 300/578 - (51%)
• Similarity: 408/578 - (70%)
• Gaps: 5/578 - (0%)

Human     7 MTGPMCLIENTNGE-LVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSLGST 70
            |..|||||.|..|| |:.|.|||:||..||||||||||||.||||||||||||||...||:||||
 Frog     6 MEEPMCLIGNKEGEDLIVNQEALQILLKITQPVVVVAIVGKYRTGKSYLMNKLAGARNGFALGST 70

Human    71 VKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTIN 135
            |:|.||||||||||||.|..:|||||||||||||:|||::||:|||:||:||||||||||||||:
 Frog    71 VQSKTKGIWMWCVPHPTKQGNTLVLLDTEGLGDVEKGDSKNDAWIFSLAILLSSTLVYNSMGTID 135

Human   136 QQAMDQLYYVTELTHRIRSKS---SPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPD 197
            |||||.|:||||||..|:.||   ...|.|:::|.:|..|||.|:|.:|||:|.||.:|.|:|.|
 Frog   136 QQAMDNLHYVTELTELIKVKSDEAQATEEEDDESGEFKRFFPSFIWCVRDFTLKLEKNGSPITED 200

Human   198 EYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQ 262
            :||..:|:|.:|..:|.:::||||.|||.:|...||||||.|.....|.:||:||:.||:.:||:
 Frog   201 QYLLDALELKKGVGKKVQDYNLPRQCIRHYFHSHKCFVFDRPASTLALQRLEELQESELESKFVE 265

Human   263 QVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQ 327
            :.|:|||.|:..|..|||.||..|.|..|.:|.::|..||..|.:|||||||:||||||||.|||
 Frog   266 KAAEFCSCIYGKSNAKTLVGGYTVTGRLLGNLAVSYTEAIRSGSIPCMENAVIALAQIENSRAVQ 330

Human   328 KAIAHYDQQMGQKV-QLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRD 391
            :|:..|:::|.::: :.|.||.:|.|.:|:..|:|||:|:|..||||.:..:||:|..:|.:|:.
 Frog   331 EALTKYEEEMSKQIAKFPTETQEEFLSIHQECEKEATQVFMGLSFKDENLEYQKQLIDELAEKKS 395

Human   392 DFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAE 456
            .:...|:|.|:.:|.|:||.:...||.|:..|.:||||||..||.:...|..:|.....||::|.
 Frog   396 KYSLYNEEESAKKCKAILQKLSENLEREILNGKFSKPGGYTQFISEKNLLVDEYNRTKGKGVKAL 460

Human   457 EILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
            ||||.:|..||:|..||||.||.||.|||||..:..:.|:|:...::|||...:.::.:|.::||
 Frog   461 EILQEFLNEKENVEAAILQADQSLTHKEKEIAEQRARTETAEREKQIVEENNRRLEKDIEAQKKS 525

Human   522 YQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQK 579
            .:||.|.:.||||.||.:|:|:.|..:..||:||..:|.:....||..|:|:|:.:::
 Frog   526 LEEHKKMMEEKMEEERKKLMEQNEWMIKEKLKEQEEMLTKGFHKESEMLKNQIEDIKR 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP3	NP_060754.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..309		183/305 (60%)
		GBP	18..280	CDD:460516	164/265 (62%)
		GBP_C	282..574	CDD:460721	126/292 (43%)
gbp5	NP_001120244.2	GBP	19..283	CDD:460516	163/263 (62%)
		GBP_C	285..582	CDD:460721	127/296 (43%)