DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP2 and gbp2

DIOPT Version :9

Sequence 1:	NP_004111.2	Gene:	GBP2 / 2634	HGNCID:	4183	Length:	591	Species:	Homo sapiens
Sequence 2:	XP_699217.2	Gene:	gbp2 / 570622	ZFINID:	ZDB-GENE-070912-618	Length:	627	Species:	Danio rerio

Alignment Length:	572	Identity:	271/572 - (47%)
Similarity:	396/572 - (69%)	Gaps:	5/572 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     6 NLPGPMSLIDNTK-GQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGS 69
            ::..|:.||:|.: |:|.|..||..||..|.:|||||::|||||||||||||:||||::||:|||
Zfish     6 HMSAPVCLIENDEFGKLCVKKEAKDILDEINEPVVVVSVVGLYRTGKSYLMNRLAGKQSGFALGS 70

Human    70 TVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTI 134
            |::|.||||||||||||.|..|||||||||||||::|||..:|:|||.||:||||..||||:|.|
Zfish    71 TIESKTKGIWMWCVPHPYKKGHTLVLLDTEGLGDVDKGDERHDTWIFCLAVLLSSALVYNSLGVI 135

Human   135 NQQAMDQLHYVTELTDRIKANSSPGN--NSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITAD 197
            :..|:::||||||||:.|:..:. ||  ...|:||:|:..||:|||.:|||||||::..:|||:|
Zfish   136 DNMALEKLHYVTELTENIRVKAE-GNEVEDEDESAEFMRVFPSFVWAVRDFTLELKMGDKPITSD 199

Human   198 DYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIE 262
            :|||.:||.:||...:...:|.||.|:|:||..||||||..||..:.:..:|.|.||||:.:|::
Zfish   200 EYLESALKPKKGNSPQIAQYNLPRRCLREFFAPRKCFVFPRPASTQDMKRMEDLTEEELDSEFLQ 264

Human   263 QVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVE 327
            |...|||||.:.:..||:.||..:.|..|.:|...||.||.||.:||:||||::||:|:|..|||
Zfish   265 QANTFCSYIYNSTEPKTVKGGRTITGTALGNLAEVYVEAIRSGKVPCLENAVVSLAKIQNVRAVE 329

Human   328 KAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDD 392
            :|:..|..:|....|.|.:. :||..:|..:|::|||.|:..||.|.||::|::|..::.....|
Zfish   330 QALQIYMTEMLSMAQFPLDP-EELSSIHTLAEKKAIEEFINMSFSDNDQIYQQELMGKIHNEYQD 393

Human   393 FCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKE 457
            .|:||.:||...|..:|:|:|.|||.::..|::.:|||||.:...|.:|.:.|....:..|.::|
Zfish   394 LCQQNHQASLMQCQEVLEDVFDPLEMNISNGSYLRPGGYREYRALLAQLTSSYRARTKSQIMSEE 458

Human   458 VLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSY 522
            ||..:|:.||||.:.:||.|:|||..|:..||:.:|.|..:..::.|||..:..|:..:..|:::
Zfish   459 VLCMFLKGKEDVGNMILQADESLSAAEQEKEVQMLKNEILQQRQRGLEEQNRLQEQAFKDMERTH 523

Human   523 QEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDI 574
            ||||.|:..:|||::.::..:.|:.|..||:|:|.|||:|||.|:.|:||:|
Zfish   524 QEHVNQIVHQMEREQERIRRDNERVLEAKLKEREALLKQGFEEEASRMQKEI 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP2	NP_004111.2	GTPase domain (Globular). /evidence=ECO:0000250	1..309		166/305 (54%)
		GBP	18..280	CDD:308078	150/264 (57%)
		GBP_C	282..578	CDD:308475	116/293 (40%)
gbp2	XP_699217.2	P-loop_NTPase	20..281	CDD:304359	149/261 (57%)
		GBP_C	284..579	CDD:202427	116/293 (40%)
		GBP_C	290..579	CDD:293879	114/287 (40%)
		coiled coil	548..559	CDD:293879	5/10 (50%)
		coiled coil	568..579	CDD:293879	4/8 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194340261
Domainoid	1	1.000	324	1.000	Domainoid score	I6643
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	565	1.000	Inparanoid score	I5681
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55037
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	1	1.000	-	-		mtm6791
orthoMCL	1	0.900	-	-		OOG6_100467
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910