Protein Alignment GBP2 and gbp1

DIOPT Version :10

• Sequence 1: NP_004111.2
• Gene: GBP2 / 2634
• HGNCID: 4183
• Length: 591
• Species: Homo sapiens
• Sequence 2: NP_001016773.1
• Gene: gbp1 / 549527
• XenbaseID: XB-GENE-6045650
• Length: 595
• Species: Xenopus tropicalis
• Alignment Length: 588
• Identity: 289/588 - (49%)
• Similarity: 409/588 - (69%)
• Gaps: 2/588 - (0%)

Human     1 MAPEINLPGPMSLIDN-TKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNG 64
            |:.:|::..|:.||:| ...:.|:|.||.:|||.||.|||||||||.||||||||||||||:|.|
 Frog     1 MSAQIHMKDPICLIENRNSNEFVINTEAEQILSQITDPVVVVAIVGKYRTGKSYLMNKLAGRKTG 65

Human    65 FSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYN 129
            |.||||::|.||||||||||||.:|.|||||||||||||:||||::||.|||:||:||||..|||
 Frog    66 FPLGSTIQSKTKGIWMWCVPHPCQPSHTLVLLDTEGLGDVEKGDSKNDGWIFSLAVLLSSNLVYN 130

Human   130 SMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPI 194
            |||||:..||:||.|||||:..||..|:|.....::..:|...||:|.|.:|||:|.||:||:.:
 Frog   131 SMGTIDNHAMEQLQYVTELSKLIKLKSNPEQEEKNEPDEFKRIFPSFTWCVRDFSLILELDGKKV 195

Human   195 TADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPD 259
            |.|:||..||||:|||||:::.:|.||.||..:|...||||||.|...:.|..||:|:|::|..|
 Frog   196 TEDEYLMNSLKLKKGTDKQTQDYNLPRECILHYFHSHKCFVFDQPTSSRNLHRLEELQEQDLEED 260

Human   260 FIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSA 324
            |::|..:||.:|.:....|||.||:.|.|..|..|...|:..|.||.:||||||||||:.:||:.
 Frog   261 FVKQTRKFCDHIHTQGVAKTLPGGLIVTGRMLAHLTSLYIETIMSGSVPCMENAVLALSVMENTG 325

Human   325 AVEKAIAHYEQQMGQKV-QLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEA 388
            ||:.|:|.||..|.:.: :.|||||||.|.||:.||:||:|||:|.||.|.:|.||::....|:.
 Frog   326 AVQDALAKYETCMKEHLPRFPTETLQEFLHLHQRSEKEALEVFLKRSFNDENQDFQKEFKNLLDN 390

Human   389 RRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGI 453
            :..:|.::|.:.|::.|..::|::...|||.:.||.|.||||:.||......:..:|...||||:
 Frog   391 KMKNFSERNERESTERCEIIIQELSEYLEERISQGEFLKPGGHNLFLVAKMTIMEEYNTTPRKGL 455

Human   454 QAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQK 518
            ::.|||::::.:|:.:..|:||.|.||:.|||.|...:.:...||..:::|||.:|..:|.||.:
 Frog   456 KSLEVLQEFISNKKGIEAAILQADVSLTAKEKEIAESQAETAEAERQRQILEENKKYLQESMENQ 520

Human   519 EKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKS 583
            :||:::|.|.|.|||:.||.:|:||.|:.:|.|||||..:|..||:.....||.:|.::..|:::
 Frog   521 KKSFEQHEKMLIEKMDADRQKLIAENERVIAQKLQEQNAMLTAGFQGRVNALQSEIDELYRRNRA 585

Human   584 LEP 586
            .:|
 Frog   586 SKP 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP2	NP_004111.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..309		172/308 (56%)
		GBP	18..280	CDD:460516	154/261 (59%)
		GBP_C	282..578	CDD:460721	125/296 (42%)
gbp1	NP_001016773.1	GBP	20..281	CDD:460516	154/260 (59%)
		GBP_C	283..579	CDD:460721	125/295 (42%)