Protein Alignment GBP2 and Gbp2

DIOPT Version :9

• Sequence 1: NP_004111.2
• Gene: GBP2 / 2634
• HGNCID: 4183
• Length: 591
• Species: Homo sapiens
• Sequence 2: NP_034390.1
• Gene: Gbp2 / 14469
• MGIID: 102772
• Length: 589
• Species: Mus musculus
• Alignment Length: 591
• Identity: 421/591 - (71%)
• Similarity: 494/591 - (83%)
• Gaps: 2/591 - (0%)

Human     1 MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGF 65
            ||.||::..||.||:||:.|||:|.|||:||||||||||||||||||||||||||||||||:.||
Mouse     1 MASEIHMSEPMCLIENTEAQLVINQEALRILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKRTGF 65

Human    66 SLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNS 130
            ||||||:||||||||||||||||...||||||||||.|:|||||:||.||||||:||||||:|||
Mouse    66 SLGSTVQSHTKGIWMWCVPHPKKAGQTLVLLDTEGLEDVEKGDNQNDCWIFALAVLLSSTFIYNS 130

Human   131 MGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPIT 195
            :|||||||||||||||||||.||:.|||..:.|||||:||.|||.||||||||:|||||:|:|:|
Mouse   131 IGTINQQAMDQLHYVTELTDLIKSKSSPDQSGVDDSANFVGFFPTFVWTLRDFSLELEVNGKPVT 195

Human   196 ADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDF 260
            :|:|||.||.|:||.|||:||||:|||||||||||||||:||.||.:|.|:.||.|:||||..:|
Mouse   196 SDEYLEHSLTLKKGADKKTKSFNEPRLCIRKFFPKRKCFIFDRPAQRKQLSKLETLREEELCGEF 260

Human   261 IEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAA 325
            :||||||.|||||:|:||||.|||.||||||:|||.|||.|||:|.|||||:|||.|||||||||
Mouse   261 VEQVAEFTSYILSYSSVKTLCGGIIVNGPRLKSLVQTYVGAISNGSLPCMESAVLTLAQIENSAA 325

Human   326 VEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARR 390
            |:|||.|||:||.||:|:|||||||||||||..|.||||||:|||||||||.||.:||..|.|:|
Mouse   326 VQKAITHYEEQMNQKIQMPTETLQELLDLHRPIESEAIEVFLKNSFKDVDQKFQTELGNLLVAKR 390

Human   391 DDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQA 455
            |.|.|:|...||..|..||:||||||||:||.|||||||||.||.|..|||:.||.|.|.||:||
Mouse   391 DAFIKKNMDVSSARCSDLLEDIFGPLEEEVKLGTFSKPGGYYLFLQMRQELEKKYNQAPGKGLQA 455

Human   456 KEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEK 520
            :.:||.|.:||.||.:.||||||||:|..|.:|.||.|||:||||.:.||:.||:.|.||:||||
Mouse   456 EAMLKNYFDSKADVVETLLQTDQSLTEAAKEVEEERTKAEAAEAANRELEKKQKEFELMMQQKEK 520

Human   521 SYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLE 585
            |||||||:|||||:.::.||:||||..:|.||:|||:.||||||||||:|.::|..::....|.:
Mouse   521 SYQEHVKKLTEKMKDEQKQLLAEQENIIAAKLREQEKFLKEGFENESKKLIREIDTLKQNKSSGK 585

Human   586 PICNIL 591
              |.||
Mouse   586 --CTIL 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP2	NP_004111.2	GTPase domain (Globular). /evidence=ECO:0000250	1..309		237/307 (77%)
		GBP	18..280	CDD:308078	205/261 (79%)
		GBP_C	282..578	CDD:308475	200/295 (68%)
Gbp2	NP_034390.1	GTPase domain (Globular). /evidence=ECO:0000250	1..309		237/307 (77%)
		GBP	18..280	CDD:280433	205/261 (79%)
		GBP_C	282..578	CDD:202427	200/295 (68%)
		GBP_C	288..578	CDD:293879	195/289 (67%)
		coiled coil	547..558	CDD:293879	6/10 (60%)
		coiled coil	567..578	CDD:293879	4/10 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83969223
Domainoid	1	1.000	427	1.000	Domainoid score	I10341
eggNOG	1	0.900	-	-		E1_KOG2037
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10289
Inparanoid	1	1.050	842	1.000	Inparanoid score	I7422
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55037
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	1	1.000	-	-		mtm9915
orthoMCL	1	0.900	-	-		OOG6_100467
Panther	1	1.100	-	-	LDO	PTHR10751
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	16.270