Protein Alignment GBP1 and gbp2

DIOPT Version :9

• Sequence 1: NP_002044.2
• Gene: GBP1 / 2633
• HGNCID: 4182
• Length: 592
• Species: Homo sapiens
• Sequence 2: XP_699217.2
• Gene: gbp2 / 570622
• ZFINID: ZDB-GENE-070912-618
• Length: 627
• Species: Danio rerio
• Alignment Length: 588
• Identity: 281/588 - (47%)
• Similarity: 404/588 - (68%)
• Gaps: 3/588 - (0%)

Human     1 MASEIHMTGPMCLIENTN-GRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKG 64
            ||...||:.|:|||||.. |:|....||..||..|.:|:|||::|||||||||||||:||||:.|
Zfish     1 MAFGRHMSAPVCLIENDEFGKLCVKKEAKDILDEINEPVVVVSVVGLYRTGKSYLMNRLAGKQSG 65

Human    65 FSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYN 129
            |:||||::|.||||||||||||.|.||.||||||||||||:|||.::|:|||.|||||||..|||
Zfish    66 FALGSTIESKTKGIWMWCVPHPYKKGHTLVLLDTEGLGDVDKGDERHDTWIFCLAVLLSSALVYN 130

Human   130 SIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQ 194
            |:|.|:..|:::|:||||||..||.|:..:|.|:| ::||:|:..||.|||.:|||:|:|:...:
Zfish   131 SLGVIDNMALEKLHYVTELTENIRVKAEGNEVEDE-DESAEFMRVFPSFVWAVRDFTLELKMGDK 194

Human   195 PLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELD 259
            |:|.||||..:||.|||.|.:...:||||.|:|:||..:|||||.||...:.:.::|.|.:||||
Zfish   195 PITSDEYLESALKPKKGNSPQIAQYNLPRRCLREFFAPRKCFVFPRPASTQDMKRMEDLTEEELD 259

Human   260 PEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIEN 324
            .||:||...|||||:::::.||:.||..:.|..|.:|...||.||.||.:||:||||::||:|:|
Zfish   260 SEFLQQANTFCSYIYNSTEPKTVKGGRTITGTALGNLAEVYVEAIRSGKVPCLENAVVSLAKIQN 324

Human   325 SAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLE 389
            ..||::|:..|..:|....|.|.:. :||..:|..:|::|||.||..||.|.|.::|:||..::.
Zfish   325 VRAVEQALQIYMTEMLSMAQFPLDP-EELSSIHTLAEKKAIEEFINMSFSDNDQIYQQELMGKIH 388

Human   390 KKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKG 454
            .:..|.|:||.:||..:|..:|:.:|.|||..:..|.|.:|||||.:...|..|...|....:..
Zfish   389 NEYQDLCQQNHQASLMQCQEVLEDVFDPLEMNISNGSYLRPGGYREYRALLAQLTSSYRARTKSQ 453

Human   455 IQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQ 519
            |.:||:|..:||.||.:.:.|||.|::|:..|:|.||:.:|.|..|...:.|:|..|..||..:.
Zfish   454 IMSEEVLCMFLKGKEDVGNMILQADESLSAAEQEKEVQMLKNEILQQRQRGLEEQNRLQEQAFKD 518

Human   520 KERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMR 584
            .||::|||:.|:..:||.::.::.::.||.|..||:|:|.|||:||::|:..|:.||..|:|.|.
Zfish   519 MERTHQEHVNQIVHQMEREQERIRRDNERVLEAKLKEREALLKQGFEEEASRMQKEINSLKTDMS 583

Human   585 RRK 587
            :::
Zfish   584 KQE 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP1	NP_002044.2	GTPase domain (Globular)	1..311		174/310 (56%)
		GBP	18..282	CDD:280433	152/264 (58%)
		GBP_C	284..580	CDD:202427	115/295 (39%)
		GBP_C	290..580	CDD:293879	113/289 (39%)
		coiled coil	549..560	CDD:293879	5/10 (50%)
		coiled coil	569..580	CDD:293879	3/10 (30%)
gbp2	XP_699217.2	P-loop_NTPase	20..281	CDD:304359	151/261 (58%)
		GBP_C	284..579	CDD:202427	115/295 (39%)
		GBP_C	290..579	CDD:293879	113/289 (39%)
		coiled coil	548..559	CDD:293879	5/10 (50%)
		coiled coil	568..579	CDD:293879	3/10 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I6643
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	565	1.000	Inparanoid score	I5681
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55037
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	1	1.000	-	-		mtm6791
orthoMCL	1	0.900	-	-		OOG6_100467
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8153
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010