Protein Alignment GBP1 and gbp1

DIOPT Version :9

• Sequence 1: NP_002044.2
• Gene: GBP1 / 2633
• HGNCID: 4182
• Length: 592
• Species: Homo sapiens
• Sequence 2: NP_001016773.1
• Gene: gbp1 / 549527
• XenbaseID: XB-GENE-6045650
• Length: 595
• Species: Xenopus tropicalis
• Alignment Length: 596
• Identity: 299/596 - (50%)
• Similarity: 409/596 - (68%)
• Gaps: 7/596 - (1%)

Human     1 MASEIHMTGPMCLIENTN-GRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKG 64
            |:::|||..|:|||||.| ...:.|.||.:|||.||.|:|||||||.||||||||||||||:|.|
 Frog     1 MSAQIHMKDPICLIENRNSNEFVINTEAEQILSQITDPVVVVAIVGKYRTGKSYLMNKLAGRKTG 65

Human    65 FSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYN 129
            |.||||:||.||||||||||||.:|.|.||||||||||||||||::||.|||:|||||||..|||
 Frog    66 FPLGSTIQSKTKGIWMWCVPHPCQPSHTLVLLDTEGLGDVEKGDSKNDGWIFSLAVLLSSNLVYN 130

Human   130 SIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQ 194
            |:|||:..||:||.|||||:..|:.||:|::.|....|  :|...||.|.|.:|||||.||.||:
 Frog   131 SMGTIDNHAMEQLQYVTELSKLIKLKSNPEQEEKNEPD--EFKRIFPSFTWCVRDFSLILELDGK 193

Human   195 PLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELD 259
            .:|.||||..||||||||.::.:.:||||.||..:|...||||||:|...|.|.:||:||:::|:
 Frog   194 KVTEDEYLMNSLKLKKGTDKQTQDYNLPRECILHYFHSHKCFVFDQPTSSRNLHRLEELQEQDLE 258

Human   260 PEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIEN 324
            .:||:|...||.:|.:....|||.||:.|.|..|..|...|:..|.||.:||||||||||:.:||
 Frog   259 EDFVKQTRKFCDHIHTQGVAKTLPGGLIVTGRMLAHLTSLYIETIMSGSVPCMENAVLALSVMEN 323

Human   325 SAAVQKAIAHYEQQMGQKV-QLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQL 388
            :.|||.|:|.||..|.:.: :.|||||||.|.||:.||:||:|||::.||.|.:..||||....|
 Frog   324 TGAVQDALAKYETCMKEHLPRFPTETLQEFLHLHQRSEKEALEVFLKRSFNDENQDFQKEFKNLL 388

Human   389 EKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRK 453
            :.|..:|.::|:..|::||..::|.:...|||.:..|.:.||||:.||:.....:.::|...|||
 Frog   389 DNKMKNFSERNERESTERCEIIIQELSEYLEERISQGEFLKPGGHNLFLVAKMTIMEEYNTTPRK 453

Human   454 GIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMME 518
            |:::.|:||.::.:|:.:..||||.|.:||.|||||...:.:...|:...::|:|.::..::.||
 Frog   454 GLKSLEVLQEFISNKKGIEAAILQADVSLTAKEKEIAESQAETAEAERQRQILEENKKYLQESME 518

Human   519 QKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKM 583
            .:::|:::|.|.|.|||:.||.:|:.|.||.:|.|||||..:|..|||.....:::||.:|..:.
 Frog   519 NQKKSFEQHEKMLIEKMDADRQKLIAENERVIAQKLQEQNAMLTAGFQGRVNALQSEIDELYRRN 583

Human   584 RRRK---ACTI 591
            |..|   .|.|
 Frog   584 RASKPKPGCII 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP1	NP_002044.2	GTPase domain (Globular)	1..311		181/310 (58%)
		GBP	18..282	CDD:280433	159/264 (60%)
		GBP_C	284..580	CDD:202427	123/296 (42%)
		GBP_C	290..580	CDD:293879	120/290 (41%)
		coiled coil	549..560	CDD:293879	6/10 (60%)
		coiled coil	569..580	CDD:293879	2/10 (20%)
gbp1	NP_001016773.1	P-loop_NTPase	20..281	CDD:304359	158/262 (60%)
		GBP_C	283..579	CDD:202427	123/295 (42%)
		GBP_C	289..579	CDD:293879	120/289 (42%)
		coiled coil	549..560	CDD:293879	6/10 (60%)
		coiled coil	569..579	CDD:293879	2/9 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	345	1.000	Domainoid score	I7575
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	596	1.000	Inparanoid score	I6507
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	1	1.000	-	-		otm54712
Panther	1	1.100	-	-	O	PTHR10751
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160