Protein Alignment GBP1 and gbp1

DIOPT Version :10

• Sequence 1: NP_002044.2
• Gene: GBP1 / 2633
• HGNCID: 4182
• Length: 592
• Species: Homo sapiens
• Sequence 2: XP_005171432.2
• Gene: gbp1 / 436615
• ZFINID: ZDB-GENE-040718-32
• Length: 622
• Species: Danio rerio
• Alignment Length: 588
• Identity: 263/588 - (44%)
• Similarity: 394/588 - (67%)
• Gaps: 8/588 - (1%)

Human     1 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGF 65
            |:....|..|:||:||.||.|....:|:..||.|.:|:|||::|||||||||||||:|||::.||
Zfish     1 MSKPTMMPSPICLVENVNGSLSICKDAIDFLSNINEPVVVVSVVGLYRTGKSYLMNRLAGQQTGF 65

Human    66 SLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNS 130
            :||:|::|.||||||||||||||.||.||||||||||||:|||::||.|||.||||||||.||||
Zfish    66 ALGNTIESKTKGIWMWCVPHPKKQGHTLVLLDTEGLGDVDKGDSKNDGWIFCLAVLLSSTLVYNS 130

Human   131 IGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQP 195
            .|||:..|:::|:|:||||.:|:.:::...:|.|.|:.:.||.|||.|.|.:|||:|||..||:.
Zfish   131 RGTIDNSALEKLHYITELTEQIKIRTAEAADEEEDEEDSKFVLFFPSFTWVVRDFTLDLVIDGKN 195

Human   196 LTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDP 260
            :..|:||.::|:|:||.::|...:||||.|||.:||.:|||||..|....|:.|||.||:::|.|
Zfish   196 VNEDQYLDFALQLRKGNNKKALEYNLPRQCIRNYFPSRKCFVFPSPASPEKMKQLESLQEKDLVP 260

Human   261 EFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENS 325
            :|::....||.:||.||..|||.||.:|.|..|..|...||:.||||.:||::|||:|||.:||.
Zfish   261 DFLEVTGRFCEHIFRNSVVKTLKGGHKVTGKLLGHLAKIYVDTISSGKVPCLDNAVVALANLENK 325

Human   326 AAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEK 390
            .||::|...||:.|.:..:.....:.|:...|:.....|...|::.||||.    ::|...||::
Zfish   326 CAVEEAFKVYERGMEEVKKTFPVNVDEISSEHQRFSSLANAEFMKRSFKDE----KQEYINQLKE 386

Human   391 KRDDF--C--KQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEP 451
            |.|.:  |  :.|..||..:|..||:.:||.:.::::.|:||:||||.|:.:....:.:||..||
Zfish   387 KIDVYYGCLLEDNGLASKKKCEDLLKDLFSEMNKKLQDGVYSQPGGYELYCKDRDVIVEKYRREP 451

Human   452 RKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQM 516
            .||:.||.:|..:|..:.:..::||.||..|||.:|:|:.|:.:....|...:..||.:.::|:|
Zfish   452 NKGVLAEAVLHEFLNERGAEANSILYTDTKLTENDKKIQEEKERNALMQQKCEEEQEKRIESERM 516

Human   517 MEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQT 581
            |..::....:.:||:.||.|.:|.|:.:|.|:.:..||:|||::|.:||::.:.::..||.||:.
Zfish   517 MAAEKVRQDDQIKQMQEKFEKEREQMQQETEKAIDSKLKEQEEMLNKGFKERADLLSEEINDLKK 581

Human   582 KMR 584
            :.:
Zfish   582 EKK 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP1	NP_002044.2	GTPase domain (Globular). /evidence=ECO:0000305|PubMed:10676968	1..311		170/309 (55%)
		GBP	18..282	CDD:460516	149/263 (57%)
		GBP_C	284..580	CDD:460721	104/299 (35%)
gbp1	XP_005171432.2	None