DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP1 and atl

DIOPT Version :9

Sequence 1:	NP_002044.2	Gene:	GBP1 / 2633	HGNCID:	4182	Length:	592	Species:	Homo sapiens
Sequence 2:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	442	Identity:	101/442 - (22%)
Similarity:	174/442 - (39%)	Gaps:	83/442 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    40 VVAIVGLYRTGKSYLM-----------------NKLAGKK---KGFSLGSTVQSHTKGIWMW--- 81
            ||::.|.:|.|||:|:                 :.|.|:.   :|||.....:..|.||.||
  Fly    40 VVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATDWLGGESDPLEGFSWRGGSERDTTGILMWSDI 104

Human    82 -CVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYV 145
             ...:|......::||||:|..| .:...::.:.:|||:.:|||..:||....|.:..:..|...
  Fly   105 FLHDYPNGDKIAIILLDTQGAFD-SQSTVRDCATVFALSTMLSSVQIYNLSQNIQEDDLQHLQLF 168

Human   146 TELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKK 210
            ||......:.:....              |....:.:||:|...||:...|..|:.|  ..:|:.
  Fly   169 TEYGRLALADTGKKP--------------FQRLQFLVRDWSFPYEAEYGALGGDKIL--KRRLEV 217

Human   211 GTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEK----LQDEELDPEFVQQVADFCS 271
            ...|..|..:| |..|...|.:..||:...|  ...:|...|    |||  :.|||...:.....
  Fly   218 SDKQHPELQSL-RRHISSCFTEVACFLMPHP--GLNVATNPKFDGRLQD--ITPEFKSSLRSLVP 277

Human   272 YIFS--NSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAH 334
            .:.:  |...|.:||. :|....|.....:|:|.....:||..::.::|.|:..:..||..|...
  Fly   278 MLLAPDNLVYKEISGQ-RVRARDLIQYFQSYMNIYKGNELPEPKSMLVATAEANHLTAVAAAKEL 341

Human   335 YEQQM-----GQKVQLPTETLQELLDLHRDSEREAIEVFI---RSSFKDVDHLFQKELAAQLEKK 391
            |.|.|     |.:..|.|..||   ..|...:.:|:..|.   :...::....|:|:|...||:.
  Fly   342 YGQLMEEVCGGTRPYLSTAHLQ---TEHLRVKDKALFQFAAKRKMGGEEFTEKFRKQLEDDLEEV 403

Human   392 RDDFCKQNQEASSDR----------CSALLQVIFSPLEEEVKAGIYSKPGGY 433
            ..::...|:..:..:          |:.::.::         :||:...|.|
  Fly   404 FTNYQAHNESKNIFKAARTPAVYFACAVIMYIL---------SGIFGLVGLY 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP1	NP_002044.2	GTPase domain (Globular)	1..311		73/300 (24%)
		GBP	18..282	CDD:280433	66/271 (24%)
		GBP_C	284..580	CDD:202427	34/168 (20%)
		GBP_C	290..580	CDD:293879	32/162 (20%)
		coiled coil	549..560	CDD:293879
		coiled coil	569..580	CDD:293879
atl	NP_001287506.1	GBP	14..289	CDD:280433	65/270 (24%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	29/143 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750