DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP1 and atln-2

DIOPT Version :9

Sequence 1:	NP_002044.2	Gene:	GBP1 / 2633	HGNCID:	4182	Length:	592	Species:	Homo sapiens
Sequence 2:	NP_502809.2	Gene:	atln-2 / 189829	WormBaseID:	WBGene00012763	Length:	520	Species:	Caenorhabditis elegans

Alignment Length:	461	Identity:	102/461 - (22%)
Similarity:	186/461 - (40%)	Gaps:	89/461 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     6 HMTGPMCLIENTN---GRLMANPEALKIL----SAITQPMVVVAIVGLYRTGKSYLMN------- 56
            |...|:.:|..::   |:...|..||..:    :...:.:|::::.|.:|.|||:|:|
Worm    25 HKVRPVQIIAPSSTQPGKFRLNESALNSVLGHSACANKKIVIISVAGAFRKGKSFLLNFFLEYLY 89

Human    57 KLAGKKK---------------GFSLGSTVQSHTKGIWMWCVP--HPKKPGHI--LVLLDTEGLG 102
            .|...::               ||...:.|:..|.|||:|..|  .....|.:  :||:||:|..
Worm    90 SLHKSQQSDSSLEWLTDDCQLHGFHWRAGVKRDTVGIWLWGEPIMIESVTGEMFAVVLMDTQGTF 154

Human   103 DVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVED 167
            | .....|....:|||:.::||..:||.:..|.:.|:..|....|. .||           .:|.
Worm   155 D-NNSTYQQCMTVFALSTIVSSVQIYNVVDNIQEDALQHLSLFVEY-GRI-----------AMEQ 206

Human   168 SADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPK 232
            ..:|...|...|:.:|||....|.:.......::|...|:.   ..::.|.....|..:|::|..
Worm   207 PHNFGKPFQQLVFCVRDFKNQEEYEFGENGGTDFLDNVLQT---NPEQPEEIKQVRELLREYFED 268

Human   233 KKCFVFDRPVHRRKLAQLEKLQD--EELDPEFVQQVADFCSYIFS---------NSKTKTLSGGI 286
            .:|::...|.:  |:|:.:..:.  ::|.|.|.:::......:..         |.||.|....|
Worm   269 IQCYLLPHPGY--KVAERQSFRGHVKDLRPLFREELKKMVPNLLGPHILKPKIVNGKTVTCRKMI 331

Human   287 QVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQK---VQLPTE 348
            |        ....|..:.....||..::.:.|.|::....|..:|..:|.:.|.:.   .::.:|
Worm   332 Q--------YFKEYAASFDGETLPQPQSILNANAKLICIEAAHEAKVNYSRGMDRSTYGTRMMSE 388

Human   349 TLQELLDLHRDSEREAIEVF---IRSSFKDVDHL----FQKELAAQLEK-------KRDDFCKQN 399
              ::||:.|......|:.:|   .|...|:|.:|    .|:::.|:|||       ||...|...
Worm   389 --KKLLEAHIKHGITALNIFDKCPRIGAKEVRNLLLEKLQEDINAELEKYKRLNEAKRVTGCASA 451

Human   400 QEASSD 405
            ..|..|
Worm   452 MLACGD 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP1	NP_002044.2	GTPase domain (Globular)	1..311		75/348 (22%)
		GBP	18..282	CDD:280433	67/307 (22%)
		GBP_C	284..580	CDD:202427	31/139 (22%)
		GBP_C	290..580	CDD:293879	29/133 (22%)
		coiled coil	549..560	CDD:293879
		coiled coil	569..580	CDD:293879
atln-2	NP_502809.2	P-loop_NTPase	41..310	CDD:393306	64/286 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820