DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP1 and atln-1

DIOPT Version :9

Sequence 1:	NP_002044.2	Gene:	GBP1 / 2633	HGNCID:	4182	Length:	592	Species:	Homo sapiens
Sequence 2:	NP_001023492.1	Gene:	atln-1 / 177059	WormBaseID:	WBGene00021868	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	440	Identity:	110/440 - (25%)
Similarity:	184/440 - (41%)	Gaps:	83/440 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    13 LIENTNGRLMANPEAL-KIL---SAITQPMVVVAIVGLYRTGKSYLMN-------------KLAG 60
            ::|:|:.....|.|.| |||   ....:.:.|:.:.|.||.|||:|:|             |:.|
Worm    38 VVEDTDHSFELNTELLEKILLDPKVADKKVAVIGVAGAYRKGKSFLLNFFLRYLTWRSKADKVMG 102

Human    61 KKK--------------GFSLGSTVQSHTKGIWMWCVPHPKKPGH----ILVLLDTEGLGDVEKG 107
            :.:              |||.....:..|.||.:|..|...|..:    .::|:||:|..| .:.
Worm   103 EVELDNSQWMSPNSPLSGFSWRGGSERDTNGILIWSEPFIMKDKNGEEIAVLLMDTQGAFD-SQS 166

Human   108 DNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFV 172
            ..::.:.||||:.::||..:||....|.:..:..|...||.            ....:||||.
Worm   167 TVKDCATIFALSTMISSVQIYNLSQNIQEDDLQHLQLFTEY------------GRLALEDSAS-- 217

Human   173 SFFPDFVWTLRDFSLDLEAD-----GQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPK 232
            ..|...::.:||:|...||:     ||.:. |..|..|.|      |..|...| |..||..|..
Worm   218 KPFQSLLFLVRDWSFPYEAEFGFQGGQRVL-DRRLEVSEK------QHAELQQL-RQHIRSCFED 274

Human   233 KKCFVFDRPVHRRKLAQLEKLQDE--ELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLES 295
            .:||:...|  ..|:|.......:  :::.||.||:......:..:......    ::||.::..
Worm   275 IRCFLMPHP--GLKVATNPNFDGKLVDIENEFQQQLGVMIPRLLDSHALVHK----EINGQKMTC 333

Human   296 LVL-----TYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKV--QLPTETLQEL 353
            ..|     .|::.....|||..::.::|.|:..|.|||..|.|.|:::|.:..  ..|..:..||
Worm   334 RELLEYFKAYMHIFRGQDLPEPKSMLMATAEANNLAAVASARAVYQREMEEVCGGDTPYMSTNEL 398

Human   354 LDLHRDSEREAIEVFIRSSFK----DVDHLFQKELAAQLEKKRDDFCKQN 399
            |:.|...:..||..| |::.|    |....|.:.|.:.|::..:::.|.|
Worm   399 LEHHDRVKNIAIREF-RNARKMGGVDFSMQFLERLESDLQESYENYLKVN 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP1	NP_002044.2	GTPase domain (Globular)	1..311		83/344 (24%)
		GBP	18..282	CDD:280433	75/305 (25%)
		GBP_C	284..580	CDD:202427	33/127 (26%)
		GBP_C	290..580	CDD:293879	32/121 (26%)
		coiled coil	549..560	CDD:293879
		coiled coil	569..580	CDD:293879
atln-1	NP_001023492.1	P-loop_NTPase	43..325	CDD:393306	75/310 (24%)
atln-1	NP_001023492.1	GBP_C	351..>447	CDD:308475	28/96 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920