Protein Alignment GBP1 and LOC100488013

DIOPT Version :10

• Sequence 1: NP_002044.2
• Gene: GBP1 / 2633
• HGNCID: 4182
• Length: 592
• Species: Homo sapiens
• Sequence 2: XP_012823014.1
• Gene: LOC100488013 / 100488013
• XenbaseID: XB-GENE-29079035
• Length: 657
• Species: Xenopus tropicalis
• Alignment Length: 583
• Identity: 294/583 - (50%)
• Similarity: 411/583 - (70%)
• Gaps: 9/583 - (1%)

Human     7 MTGPMCLIENTNG-RLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKK---KGFSL 67
            |..|||||||..| .|..|.|||:||..||||:|||||||.||||||||||.|||.:   .||:|
 Frog    34 MGEPMCLIENKEGEELTVNQEALEILLEITQPVVVVAIVGKYRTGKSYLMNILAGARNEHSGFAL 98

Human    68 GSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIG 132
            ||||:|.||||||||||||.|.||.||||||||||||||||::||:|||:||:|||||.||||:|
 Frog    99 GSTVRSKTKGIWMWCVPHPTKKGHTLVLLDTEGLGDVEKGDSKNDAWIFSLAILLSSTLVYNSMG 163

Human   133 TINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLT 197
            ||:|||||.|:||||||.||:.||...:.| :::::.:|..|||.|:|.:|||:|.||.||.|:|
 Frog   164 TIDQQAMDNLHYVTELTERIKVKSHEGKAE-DMDETGEFKRFFPSFIWCVRDFTLQLEKDGVPIT 227

Human   198 PDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEF 262
            .|:||..:|:||:|..:|.:.:||||.|||.:|...||||||||..:..|.:||:||:.||:.||
 Frog   228 EDQYLMDALELKRGVGKKVQDYNLPRQCIRHYFHSHKCFVFDRPASKADLQRLEELQESELELEF 292

Human   263 VQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAA 327
            |.:...|||:|..:...|||.||..|.|..|.:|...|..||.||.:|||||||.|||..|||.|
 Frog   293 VDKAITFCSFINQHCNAKTLVGGTIVTGRTLGNLTDLYTEAIRSGSIPCMENAVKALADRENSRA 357

Human   328 VQKAIAHYEQQMGQKV-QLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKK 391
            ||:|:..||::|.::: :.||||.:|.|.:|::.|:||.:||:..||||.:..:|.:|..:|.::
 Frog   358 VQEALTKYEEEMSKQIAKFPTETQEEFLSIHQECEKEATKVFMGLSFKDENGQYQNQLIDELAEE 422

Human   392 RDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQ 456
            :..:...|:|.|:.:|.|:||.:...||.|:..|.:||||||..|:.:...|..||.:...||::
 Frog   423 KSKYSLHNEEESAKKCKAILQKLNESLEREISEGKFSKPGGYTQFISEKNLLVDKYNKTKGKGVK 487

Human   457 AEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKE 521
            |.||::.:|..|:.:.::|||.||:||..|||||.:|.:.|:|:...::::|..|:.|:.||.::
 Frog   488 APEIIEEFLNEKKIVEESILQADQSLTATEKEIEEQRARTETAEREKQIVEENNRRLEKDMENQK 552

Human   522 RSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNE---IQDLQT 581
            :|.::|.|.|.||||.:|.:|:::.|..:..||:|.::|||:||..:|.|:|.:   :::|.|
 Frog   553 KSLEDHKKMLEEKMEEERKKLMEQNEWMIKEKLKEADELLKKGFDAQSEIVKYQSRLLKELNT 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP1	NP_002044.2	GTPase domain (Globular). /evidence=ECO:0000305|PubMed:10676968	1..311		183/307 (60%)
		GBP	18..282	CDD:460516	162/267 (61%)
		GBP_C	284..580	CDD:460721	120/299 (40%)
LOC100488013	XP_012823014.1	GBP	47..312	CDD:460516	161/265 (61%)
		GBP_C	314..601	CDD:460721	117/286 (41%)