DRSC/TRiP Functional Genomics Resources

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Protein Alignment GBP1 and si:dkeyp-30d6.2

DIOPT Version :9

Sequence 1:NP_002044.2 Gene:GBP1 / 2633 HGNCID:4182 Length:592 Species:Homo sapiens
Sequence 2:NP_001353308.1 Gene:si:dkeyp-30d6.2 / 100322630 ZFINID:ZDB-GENE-141222-83 Length:378 Species:Danio rerio


Alignment Length:377 Identity:202/377 - (53%)
Similarity:266/377 - (70%) Gaps:9/377 - (2%)


- Green bases have known domain annotations that are detailed below.


Human     7 MTGPMCLIE-NTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGST 70
            |..|:|||. :::|:|...|.||::|..|.||:||||:|||||||||||||.||||:.||:||.|
Zfish     1 MDKPVCLINTDSDGKLYVQPAALQVLQQIQQPVVVVAVVGLYRTGKSYLMNHLAGKQTGFALGGT 65

Human    71 VQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTIN 135
            ::|.||||||||||||.|.|..||||||||||||||||:::|:.||.||||||||.||||.||||
Zfish    66 IESKTKGIWMWCVPHPTKTGTTLVLLDTEGLGDVEKGDSKHDTNIFCLAVLLSSTLVYNSRGTIN 130

Human   136 QQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDE 200
            .:|:::|.||||||..|:.|||    :.:|:||.:||.|||.|:|::|||:|:.:.||:..|.||
Zfish   131 NRAIEELQYVTELTECIKVKSS----DEDVDDSTEFVKFFPSFIWSVRDFTLERKIDGKDATEDE 191

Human   201 YLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQ 265
            ||.::||||.|||:|..:|||||.||:||||.:.||.|..|....|::.||.|...:|..||::.
Zfish   192 YLEFALKLKPGTSKKITSFNLPRECIQKFFPTRTCFTFPFPTAPEKMSTLESLSPADLSTEFLEV 256

Human   266 VADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQK 330
            ...||.::|..|:.|.|..|..|.|..|.:|...|||.||||.:||:||||:|:|||||.||.|:
Zfish   257 TKRFCKFVFDKSEVKRLKDGHTVTGRVLGNLTKMYVNTISSGAVPCLENAVIAMAQIENVAATQE 321

Human   331 AIAHYEQQMGQ-KVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVD--HL 379
            .:..|::.|.: |...|.| |:::...|:....:|.:.|:..||||.|  ||
Zfish   322 GLEVYQRGMEKVKCSFPLE-LEQVSSEHQRLSSKATQAFMARSFKDTDGKHL 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GBP1NP_002044.2 GTPase domain (Globular) 1..311 171/304 (56%)
GBP 18..282 CDD:280433 153/263 (58%)
GBP_C 284..580 CDD:202427 43/99 (43%)
GBP_C 290..580 CDD:293879 41/93 (44%)
coiled coil 549..560 CDD:293879
coiled coil 569..580 CDD:293879
si:dkeyp-30d6.2NP_001353308.1 P-loop_NTPase 13..273 CDD:328724 153/263 (58%)
GBP_C 281..>376 CDD:328214 41/93 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H133759
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1027269at2759
OrthoFinder 1 1.000 - - FOG0000238
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.920

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