Protein Alignment GBP1 and gbp6

DIOPT Version :9

• Sequence 1: NP_002044.2
• Gene: GBP1 / 2633
• HGNCID: 4182
• Length: 592
• Species: Homo sapiens
• Sequence 2: NP_001120628.1
• Gene: gbp6 / 100145795
• XenbaseID: XB-GENE-6050518
• Length: 628
• Species: Xenopus tropicalis
• Alignment Length: 589
• Identity: 286/589 - (48%)
• Similarity: 416/589 - (70%)
• Gaps: 16/589 - (2%)

Human     1 MASEIHMTGPMCLIENTNG----RLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGK 61
            |:..:.|:.|:|||||.|.    :|:.|.:|::||..||:|:|.|||||.||||||||||||||.
 Frog     1 MSRGVVMSHPVCLIENQNTPEGYKLVINQKAVQILEDITEPVVPVAIVGKYRTGKSYLMNKLAGS 65

Human    62 KKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTF 126
            ..||:||||:||.||||||||||||.||||.||||||||||||||||.:||||:|:||||||||.
 Frog    66 NDGFALGSTIQSKTKGIWMWCVPHPHKPGHTLVLLDTEGLGDVEKGDRKNDSWVFSLAVLLSSTL 130

Human   127 VYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEA 191
            ||||:|||:|:::::|:||||||.||:.|:   :..|:.::||:|...||.|:|.:|||:|.||.
 Frog   131 VYNSVGTIDQESLEKLHYVTELTERIKLKA---KTSNDDDESAEFKRTFPSFIWCVRDFTLKLEQ 192

Human   192 DGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDE 256
            :|:.:|.||||..:|.||.|.|:....:|.||.||..||...|||||:||.....|.:||:|.:.
 Frog   193 EGKQITEDEYLQMALNLKPGFSKAAREYNFPRECITHFFHSHKCFVFERPASTEDLQRLEELSES 257

Human   257 ELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQ 321
            :|:|.||:|...||.::|:||:||||:||..|.|..|.:|.:|||.:|.||.:||||||||||||
 Frog   258 QLEPRFVKQAHRFCDFVFNNSQTKTLAGGHCVTGRMLGTLAVTYVESIRSGSVPCMENAVLALAQ 322

Human   322 IENSAAVQKAIAHYEQQMGQ-KVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELA 385
            |||:||:|||::.||.:|.| :...||||..|.|......|::|::||:..||||....:|.:|.
 Frog   323 IENTAAIQKALSVYEAEMKQAEGTFPTETQDEFLSKQTQCEKKAVKVFMDRSFKDDKREYQGKLM 387

Human   386 AQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEE 450
            ..|::|..:|.|:|:|||..:|..||||:.:.||:.:|..::|||||::.::::.|.:...|...
 Frog   388 GDLQQKHQEFAKRNEEASIHKCQDLLQVLSANLEKGIKNVVFSKPGGHKQYLKEKQKIMDTYNNS 452

Human   451 PRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQ 515
            |.|||:|..:||.:::.|:::...:||.|::||:::||:|.|::|.|:|:   |.||| :::|.:
 Frog   453 PGKGIKAALVLQQFIEGKKNIEMTVLQADESLTKQQKEMEEEKMKKEAAE---KKLQE-EKENAR 513

Human   516 MMEQKERSYQEHLKQ----LTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEI 576
            .:|:..:...:.|:|    |.||:|.:|..||||.|..:..|::|:|:|.:||...::.::..::
 Frog   514 QLERTRKEQTQRLEQQAIMLKEKLEEERHMLLKENEWMIKEKMKEREKLAQEGLHNKAGMLGEQV 578

Human   577 QDLQ 580
            ..||
 Frog   579 NALQ 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP1	NP_002044.2	GTPase domain (Globular)	1..311		177/313 (57%)
		GBP	18..282	CDD:280433	155/267 (58%)
		GBP_C	284..580	CDD:202427	119/300 (40%)
		GBP_C	290..580	CDD:293879	116/294 (39%)
		coiled coil	549..560	CDD:293879	3/10 (30%)
		coiled coil	569..580	CDD:293879	0/10 (0%)
gbp6	NP_001120628.1	P-loop_NTPase	25..283	CDD:422963	154/260 (59%)
		GBP_C	291..582	CDD:293879	116/294 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	345	1.000	Domainoid score	I7575
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	596	1.000	Inparanoid score	I6507
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10751
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160