Protein Alignment GBP1 and gbp6

DIOPT Version :10

• Sequence 1: NP_002044.2
• Gene: GBP1 / 2633
• HGNCID: 4182
• Length: 592
• Species: Homo sapiens
• Sequence 2: NP_001120628.1
• Gene: gbp6 / 100145795
• XenbaseID: XB-GENE-6050518
• Length: 628
• Species: Xenopus tropicalis
• Alignment Length: 589
• Identity: 286/589 - (48%)
• Similarity: 416/589 - (70%)
• Gaps: 16/589 - (2%)

Human     1 MASEIHMTGPMCLIENTNG----RLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGK 61
            |:..:.|:.|:|||||.|.    :|:.|.:|::||..||:|:|.|||||.||||||||||||||.
 Frog     1 MSRGVVMSHPVCLIENQNTPEGYKLVINQKAVQILEDITEPVVPVAIVGKYRTGKSYLMNKLAGS 65

Human    62 KKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTF 126
            ..||:||||:||.||||||||||||.||||.||||||||||||||||.:||||:|:||||||||.
 Frog    66 NDGFALGSTIQSKTKGIWMWCVPHPHKPGHTLVLLDTEGLGDVEKGDRKNDSWVFSLAVLLSSTL 130

Human   127 VYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEA 191
            ||||:|||:|:::::|:||||||.||:.|:   :..|:.::||:|...||.|:|.:|||:|.||.
 Frog   131 VYNSVGTIDQESLEKLHYVTELTERIKLKA---KTSNDDDESAEFKRTFPSFIWCVRDFTLKLEQ 192

Human   192 DGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDE 256
            :|:.:|.||||..:|.||.|.|:....:|.||.||..||...|||||:||.....|.:||:|.:.
 Frog   193 EGKQITEDEYLQMALNLKPGFSKAAREYNFPRECITHFFHSHKCFVFERPASTEDLQRLEELSES 257

Human   257 ELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQ 321
            :|:|.||:|...||.::|:||:||||:||..|.|..|.:|.:|||.:|.||.:||||||||||||
 Frog   258 QLEPRFVKQAHRFCDFVFNNSQTKTLAGGHCVTGRMLGTLAVTYVESIRSGSVPCMENAVLALAQ 322

Human   322 IENSAAVQKAIAHYEQQMGQ-KVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELA 385
            |||:||:|||::.||.:|.| :...||||..|.|......|::|::||:..||||....:|.:|.
 Frog   323 IENTAAIQKALSVYEAEMKQAEGTFPTETQDEFLSKQTQCEKKAVKVFMDRSFKDDKREYQGKLM 387

Human   386 AQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEE 450
            ..|::|..:|.|:|:|||..:|..||||:.:.||:.:|..::|||||::.::::.|.:...|...
 Frog   388 GDLQQKHQEFAKRNEEASIHKCQDLLQVLSANLEKGIKNVVFSKPGGHKQYLKEKQKIMDTYNNS 452

Human   451 PRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQ 515
            |.|||:|..:||.:::.|:::...:||.|::||:::||:|.|::|.|:|:   |.||| :::|.:
 Frog   453 PGKGIKAALVLQQFIEGKKNIEMTVLQADESLTKQQKEMEEEKMKKEAAE---KKLQE-EKENAR 513

Human   516 MMEQKERSYQEHLKQ----LTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEI 576
            .:|:..:...:.|:|    |.||:|.:|..||||.|..:..|::|:|:|.:||...::.::..::
 Frog   514 QLERTRKEQTQRLEQQAIMLKEKLEEERHMLLKENEWMIKEKMKEREKLAQEGLHNKAGMLGEQV 578

Human   577 QDLQ 580
            ..||
 Frog   579 NALQ 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP1	NP_002044.2	GTPase domain (Globular). /evidence=ECO:0000305|PubMed:10676968	1..311		177/313 (57%)
		GBP	18..282	CDD:460516	155/267 (58%)
		GBP_C	284..580	CDD:460721	119/300 (40%)
gbp6	NP_001120628.1	GBP	25..283	CDD:460516	154/260 (59%)
		GBP_C	291..582	CDD:293879	116/294 (39%)
		coiled coil	551..562	CDD:293879	3/10 (30%)
		coiled coil	571..582	CDD:293879	0/10 (0%)