Protein Alignment GBP1 and gbp5

DIOPT Version :10

• Sequence 1: NP_002044.2
• Gene: GBP1 / 2633
• HGNCID: 4182
• Length: 592
• Species: Homo sapiens
• Sequence 2: NP_001120244.2
• Gene: gbp5 / 100145295
• XenbaseID: XB-GENE-5756296
• Length: 636
• Species: Xenopus tropicalis
• Alignment Length: 581
• Identity: 307/581 - (52%)
• Similarity: 421/581 - (72%)
• Gaps: 7/581 - (1%)

Human     7 MTGPMCLIENTNGR-LMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGST 70
            |..|||||.|..|. |:.|.|||:||..||||:|||||||.||||||||||||||.:.||:||||
 Frog     6 MEEPMCLIGNKEGEDLIVNQEALQILLKITQPVVVVAIVGKYRTGKSYLMNKLAGARNGFALGST 70

Human    71 VQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTIN 135
            |||.||||||||||||.|.|:.||||||||||||||||::||:|||:||:|||||.||||:|||:
 Frog    71 VQSKTKGIWMWCVPHPTKQGNTLVLLDTEGLGDVEKGDSKNDAWIFSLAILLSSTLVYNSMGTID 135

Human   136 QQAMDQLYYVTELTHRIRSKSSPDE---NENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLT 197
            |||||.|:||||||..|:.||  ||   .|.|.::|.:|..|||.|:|.:|||:|.||.:|.|:|
 Frog   136 QQAMDNLHYVTELTELIKVKS--DEAQATEEEDDESGEFKRFFPSFIWCVRDFTLKLEKNGSPIT 198

Human   198 PDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEF 262
            .|:||..:|:||||..:|.:.:||||.|||.:|...||||||||.....|.:||:||:.||:.:|
 Frog   199 EDQYLLDALELKKGVGKKVQDYNLPRQCIRHYFHSHKCFVFDRPASTLALQRLEELQESELESKF 263

Human   263 VQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAA 327
            |::.|:|||.|:..|..|||.||..|.|..|.:|.::|..||.||.:|||||||:||||||||.|
 Frog   264 VEKAAEFCSCIYGKSNAKTLVGGYTVTGRLLGNLAVSYTEAIRSGSIPCMENAVIALAQIENSRA 328

Human   328 VQKAIAHYEQQMGQKV-QLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKK 391
            ||:|:..||::|.::: :.||||.:|.|.:|::.|:||.:||:..||||.:..:||:|..:|.:|
 Frog   329 VQEALTKYEEEMSKQIAKFPTETQEEFLSIHQECEKEATQVFMGLSFKDENLEYQKQLIDELAEK 393

Human   392 RDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQ 456
            :..:...|:|.|:.:|.|:||.:...||.|:..|.:||||||..|:.:...|..:|.....||::
 Frog   394 KSKYSLYNEEESAKKCKAILQKLSENLEREILNGKFSKPGGYTQFISEKNLLVDEYNRTKGKGVK 458

Human   457 AEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKE 521
            |.||||.:|..||::..||||.||:||.|||||..:|.:.|:|:...::::|..|:.|:.:|.::
 Frog   459 ALEILQEFLNEKENVEAAILQADQSLTHKEKEIAEQRARTETAEREKQIVEENNRRLEKDIEAQK 523

Human   522 RSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTK 582
            :|.:||.|.:.||||.:|.:|:::.|..:..||:|||::|.:||.|||.::||:|:|::.|
 Frog   524 KSLEEHKKMMEEKMEEERKKLMEQNEWMIKEKLKEQEEMLTKGFHKESEMLKNQIEDIKRK 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP1	NP_002044.2	GTPase domain (Globular). /evidence=ECO:0000305|PubMed:10676968	1..311		187/307 (61%)
		GBP	18..282	CDD:460516	167/267 (63%)
		GBP_C	284..580	CDD:460721	130/296 (44%)
gbp5	NP_001120244.2	GBP	19..283	CDD:460516	166/265 (63%)
		GBP_C	285..582	CDD:460721	130/296 (44%)